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IFT122 intraflagellar transport 122 [ Homo sapiens (human) ]

Gene ID: 55764, updated on 11-Apr-2024

Summary

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Official Symbol
IFT122provided by HGNC
Official Full Name
intraflagellar transport 122provided by HGNC
Primary source
HGNC:HGNC:13556
See related
Ensembl:ENSG00000163913 MIM:606045; AllianceGenome:HGNC:13556
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CED; SPG; CED1; FAP80; WDR10; CFAP80; WDR10p; WDR140
Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This cytoplasmic protein contains seven WD repeats and an AF-2 domain which function by recruiting coregulatory molecules and in transcriptional activation. Mutations in this gene cause cranioectodermal dysplasia-1. A related pseudogene is located on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Expression
Broad expression in testis (RPKM 41.7), ovary (RPKM 7.5) and 15 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
3q21.3-q22.1
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (129440224..129520507)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (132185050..132264949)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (129159067..129239350)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:129129626-129130126 Neighboring gene EF-hand calcium binding domain 12 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:129137243-129137742 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20511 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14724 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20512 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20513 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20514 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20517 Neighboring gene methyl-CpG binding domain 4, DNA glycosylase Neighboring gene Sharpr-MPRA regulatory region 8693 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:129168229-129168945 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:129200162-129201039 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:129208521-129208729 Neighboring gene Sharpr-MPRA regulatory region 10640 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:129213542-129214741 Neighboring gene MPRA-validated peak4826 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:129247433-129248158 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:129248159-129248884 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:129253999-129254668 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:129261557-129262058 Neighboring gene rhodopsin enhancer region Neighboring gene Sharpr-MPRA regulatory region 2951 Neighboring gene rhodopsin Neighboring gene H1.8 linker histone

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Case series of autosomal recessive hereditary spastic paraparesis with novel mutation in SPG 7 gene. Bhattacharjee S, et al. Neurosciences (Riyadh), 2017 Oct. PMID 29057857, Free PMC Article
  2. Beemer-Langer syndrome is a ciliopathy due to biallelic mutations in IFT122. Silveira KC, et al. Am J Med Genet A, 2017 May. PMID 28370949
  3. Novel IFT122 mutations in three Argentinian patients with cranioectodermal dysplasia: Expanding the mutational spectrum. Moosa S, et al. Am J Med Genet A, 2016 May. PMID 26792575
  4. Whole exome sequencing revealed biallelic IFT122 mutations in a family with CED1 and recurrent pregnancy loss. Tsurusaki Y, et al. Clin Genet, 2014 Jun. PMID 23826986
  5. Cloning and characterization of human WDR10, a novel gene located at 3q21 encoding a WD-repeat protein that is highly expressed in pituitary and testis. Gross C, et al. DNA Cell Biol, 2001 Jan. PMID 11242542

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study demonstrated that the mutation in SPG 7 gene caused autosomal recessive hereditary spastic paraparesis.
    Title: Case series of autosomal recessive hereditary spastic paraparesis with novel mutation in SPG 7 gene.
  2. The C11ORF74, interacts with the IFT-A complex via the IFT122 subunit and is accumulated at the distal tip in the absence of an IFT-A subunit IFT139, suggesting that at least a fraction of C11ORF74 molecules can be transported towards the ciliary tip by associating with the IFT-A complex, although its majority might be out of cilia at steady state.
    Title: C11ORF74 interacts with the IFT-A complex and participates in ciliary BBSome localization.
  3. IFT122 mutations associated with cranioectodermal dysplasia 1 cause defects in ciliary protein trafficking, but not ciliogenesis when expressed in cells lacking endogenous IFT122 (IFT122 KO).
    Title: Ciliopathy-associated mutations of IFT122 impair ciliary protein trafficking but not ciliogenesis.
  4. All the nine probands with syndromic craniosynostosis were found to carry the possibly causative variants, among which three variants including two missense mutations in IFT122 gene, in SMC1A gene and a frameshift mutation in TWIST1 gene have never been reported in patients before.
    Title: Identification and analysis of the genetic causes in nine unrelated probands with syndromic craniosynostosis.
  5. Using a panel of skeletal dysplasias genes, including 11 related to SRP, we identified biallelic mutations in IFT122 in a fetus with a typical phenotype of SRP-IV, finally confirmed that this phenotype is a ciliopathy and adding to the list of ciliopathies with major skeletal involvement.
    Title: Beemer-Langer syndrome is a ciliopathy due to biallelic mutations in IFT122.
  6. The three patients had different, novel, compound heterozygous mutations in IFT122. Consequently, we compared these three patients to those previously described with IFT122 mutations. Thus, our report serves to add 6 novel mutations to the IFT122 mutation spectrum and to contribute to the IFT122-related clinical characterization.
    Title: Novel IFT122 mutations in three Argentinian patients with cranioectodermal dysplasia: Expanding the mutational spectrum.
  7. this study was able to find causative IFT122 mutations in a non-consanguineous family with recurrent abortions.
    Title: Whole exome sequencing revealed biallelic IFT122 mutations in a family with CED1 and recurrent pregnancy loss.
  8. we found a homozygous missense mutation in the IFT122 (WDR10) gene that cosegregated with Sensenbrenner syndrome
    Title: Cranioectodermal Dysplasia, Sensenbrenner syndrome, is a ciliopathy caused by mutations in the IFT122 gene.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Cranioectodermal dysplasia 1
MedGen: C0432235 OMIM: 218330 GeneReviews: Cranioectodermal Dysplasia
Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with intraflagellar transport 122 homolog (IFT122) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in camera-type eye morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cilium assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in embryonic body morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in embryonic forelimb morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in embryonic heart tube development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in embryonic heart tube left/right pattern formation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in establishment of protein localization to organelle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intraciliary anterograde transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intraciliary retrograde transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intraciliary retrograde transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intraciliary retrograde transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in intraciliary transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in limb development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of smoothened signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neural tube closure ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in non-motile cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein localization to cilium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to cilium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spinal cord dorsal/ventral patterning ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary tip TAS
Traceable Author Statement
more info
  
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cilium ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cilium NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cilium TAS
Traceable Author Statement
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of intraciliary transport particle A IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of intraciliary transport particle A IDA
Inferred from Direct Assay
more info
 PubMed 
part_of intraciliary transport particle A IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in membrane HDA PubMed 
is_active_in non-motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in photoreceptor connecting cilium ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
intraflagellar transport protein 122 homolog
Names
WD repeat domain 10
WD repeat-containing protein 10
WD repeat-containing protein 140
intraflagellar transport 122 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023392.1 RefSeqGene

    Range
    5100..85383
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001280541.2 → NP_001267470.1  intraflagellar transport protein 122 homolog isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 5' coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 5, which is shorter than isoform 1.
    Source sequence(s)
    AF244931, AK315103, BC028353, BF941125, DB516647
    Consensus CDS
    CCDS63770.1
    UniProtKB/TrEMBL
    A0A8I5KP73
    Related
    ENSP00000425536.1, ENST00000507564.5
    Conserved Domains (3) summary
    COG2319
    Location:4 → 340
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:15 → 51
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:49 → 341
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001280545.2 → NP_001267474.1  intraflagellar transport protein 122 homolog isoform 6

    See identical proteins and their annotated locations for NP_001267474.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate exon and contains an alternate exon in the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 6, which is shorter than isoform 1.
    Source sequence(s)
    AF244930, AK096891, AK124140, BF941125, DB099554, DB516647
    UniProtKB/TrEMBL
    B4DST2
    Conserved Domains (3) summary
    COG2319
    Location:2 → 200
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:133 → 167
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:134 → 200
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. NM_001280546.2 → NP_001267475.1  intraflagellar transport protein 122 homolog isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks three alternate exons in the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 7, which is shorter than isoform 1.
    Source sequence(s)
    AK096891, AK124140, AK298526, AK299903, BF941125, DB099554, DB516647
    UniProtKB/TrEMBL
    B4DST2
    Related
    ENSP00000509186.1, ENST00000693233.1
    Conserved Domains (3) summary
    COG2319
    Location:24 → 141
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:30 → 64
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:24 → 142
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. NM_001410808.1 → NP_001397737.1  intraflagellar transport protein 122 homolog isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC080007, AL449212
    Consensus CDS
    CCDS93372.1
    UniProtKB/TrEMBL
    A0A8I5KSG5
    Related
    ENSP00000509878.1, ENST00000692242.1

  5. NM_001410809.1 → NP_001397738.1  intraflagellar transport protein 122 homolog isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC080007, AL449212
    Consensus CDS
    CCDS93374.1
    UniProtKB/TrEMBL
    A0A8I5KVC7
    Related
    ENSP00000509806.1, ENST00000693129.1

  6. NM_001410810.1 → NP_001397739.1  intraflagellar transport protein 122 homolog isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC080007, AL449212
    Consensus CDS
    CCDS93375.1
    UniProtKB/TrEMBL
    A0A8I5KWK4
    Related
    ENSP00000510425.1, ENST00000689332.1

  7. NM_001410811.1 → NP_001397740.1  intraflagellar transport protein 122 homolog isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC080007, AL449212
    Consensus CDS
    CCDS93376.1
    UniProtKB/TrEMBL
    A0A8I5QKX8
    Related
    ENSP00000509982.1, ENST00000689801.1

  8. NM_001410813.1 → NP_001397742.1  intraflagellar transport protein 122 homolog isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC080007, AL449212
    Consensus CDS
    CCDS93377.1
    UniProtKB/TrEMBL
    A0A8I5KTL4
    Related
    ENSP00000510741.1, ENST00000691583.1

  9. NM_001410815.1 → NP_001397744.1  intraflagellar transport protein 122 homolog isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC080007, AL449212
    Consensus CDS
    CCDS93379.1
    UniProtKB/TrEMBL
    A0A8I5KT04
    Related
    ENSP00000509216.1, ENST00000693588.1

  10. NM_001410817.1 → NP_001397746.1  intraflagellar transport protein 122 homolog isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC080007, AL449212
    Consensus CDS
    CCDS93380.1
    UniProtKB/TrEMBL
    A0A8J9A3C6
    Related
    ENSP00000422179.2, ENST00000504021.6

  11. NM_018262.4 → NP_060732.2  intraflagellar transport protein 122 homolog isoform 3

    See identical proteins and their annotated locations for NP_060732.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 5' coding region, compared to variant 1. It encodes isoform 3, which lacks two internal segments and is shorter than isoform 1.
    Source sequence(s)
    AK001759, BC028353, BF941125, DB516647
    Consensus CDS
    CCDS3059.1
    UniProtKB/TrEMBL
    A0A8I5KSV0
    Related
    ENSP00000323973.3, ENST00000347300.6
    Conserved Domains (3) summary
    COG2319
    Location:15 → 289
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:15 → 51
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:49 → 291
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  12. NM_052985.4 → NP_443711.2  intraflagellar transport protein 122 homolog isoform 1

    See identical proteins and their annotated locations for NP_443711.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF244931, AK298526, BF941125, DB516647
    Consensus CDS
    CCDS3060.1
    UniProtKB/TrEMBL
    A0A8I5KP73
    Related
    ENSP00000296266.3, ENST00000296266.7
    Conserved Domains (3) summary
    COG2319
    Location:15 → 240
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:15 → 51
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:12 → 241
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  13. NM_052989.3 → NP_443715.1  intraflagellar transport protein 122 homolog isoform 2

    See identical proteins and their annotated locations for NP_443715.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter that isoform 1.
    Source sequence(s)
    AF244931, AF302154, BF941125, DB099554, DB516647
    Consensus CDS
    CCDS3061.1
    UniProtKB/Swiss-Prot
    B3KW53, B4DEY9, B4DPW7, E7EQF4, E9PDG2, E9PDX2, G3XAB1, H7C3C0, Q53G36, Q8TC06, Q9BTB9, Q9BTY4, Q9HAT9, Q9HBG5, Q9HBG6, Q9NV68, Q9UF80
    UniProtKB/TrEMBL
    A0A8I5QKV2
    Related
    ENSP00000324005.4, ENST00000348417.7
    Conserved Domains (3) summary
    COG2319
    Location:4 → 348
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:15 → 51
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:15 → 190
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  14. NM_052990.3 → NP_443716.1  intraflagellar transport protein 122 homolog isoform 4

    See identical proteins and their annotated locations for NP_443716.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks four alternate exons in the 5' coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 4, which lacks two in-frame segments and is shorter, compared to isoform 1.
    Source sequence(s)
    AK298526, BC003045, BF941125, DB099554, DB516647
    Consensus CDS
    CCDS3062.1
    UniProtKB/TrEMBL
    A0A8I5QL25
    Related
    ENSP00000324165.3, ENST00000349441.6
    Conserved Domains (3) summary
    COG2319
    Location:15 → 237
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:15 → 51
    7WD40; WD40 repeat [structural motif]
    cl26002
    Location:599 → 807
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    129440224..129520507
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713691.4 → XP_006713754.1  intraflagellar transport protein 122 homolog isoform X1

    UniProtKB/TrEMBL
    A0A8I5KXT5, A0A8I5QKV2
    Related
    ENSP00000509225.1, ENST00000687377.1
    Conserved Domains (3) summary
    COG2319
    Location:4 → 348
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:15 → 51
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:15 → 190
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_047448546.1 → XP_047304502.1  intraflagellar transport protein 122 homolog isoform X2

  3. XM_047448547.1 → XP_047304503.1  intraflagellar transport protein 122 homolog isoform X3

    UniProtKB/TrEMBL
    A0A8I5KUU2
    Related
    ENSP00000508904.1, ENST00000688020.1

  4. XM_047448548.1 → XP_047304504.1  intraflagellar transport protein 122 homolog isoform X4

  5. XM_047448549.1 → XP_047304505.1  intraflagellar transport protein 122 homolog isoform X5

  6. XM_017006834.3 → XP_016862323.1  intraflagellar transport protein 122 homolog isoform X6

    UniProtKB/TrEMBL
    A0A8I5QKR8, A0A8I5QL25
    Related
    ENSP00000509297.1, ENST00000690663.1

  7. XM_047448552.1 → XP_047304508.1  intraflagellar transport protein 122 homolog isoform X7

  8. XM_011512972.4 → XP_011511274.1  intraflagellar transport protein 122 homolog isoform X8

    UniProtKB/TrEMBL
    A0A8I5KNX7
    Related
    ENSP00000508811.1, ENST00000690723.1
    Conserved Domains (3) summary
    COG2319
    Location:4 → 348
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:15 → 51
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:15 → 190
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  9. XM_006713695.4 → XP_006713758.1  intraflagellar transport protein 122 homolog isoform X9

    UniProtKB/TrEMBL
    A0A8I5KS91
    Related
    ENSP00000508642.1, ENST00000685282.1
    Conserved Domains (3) summary
    COG2319
    Location:4 → 348
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:15 → 51
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:15 → 190
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  10. XM_047448553.1 → XP_047304509.1  intraflagellar transport protein 122 homolog isoform X10

    Related
    ENSP00000509155.1, ENST00000685447.1

  11. XM_047448551.1 → XP_047304507.1  intraflagellar transport protein 122 homolog isoform X7

  12. XM_047448554.1 → XP_047304510.1  intraflagellar transport protein 122 homolog isoform X11

    Related
    ENSP00000508740.1, ENST00000688527.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    132185050..132264949
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054347220.1 → XP_054203195.1  intraflagellar transport protein 122 homolog isoform X1

  2. XM_054347221.1 → XP_054203196.1  intraflagellar transport protein 122 homolog isoform X2

  3. XM_054347222.1 → XP_054203197.1  intraflagellar transport protein 122 homolog isoform X3

  4. XM_054347223.1 → XP_054203198.1  intraflagellar transport protein 122 homolog isoform X4

  5. XM_054347224.1 → XP_054203199.1  intraflagellar transport protein 122 homolog isoform X5

  6. XM_054347225.1 → XP_054203200.1  intraflagellar transport protein 122 homolog isoform X6

  7. XM_054347227.1 → XP_054203202.1  intraflagellar transport protein 122 homolog isoform X7

  8. XM_054347228.1 → XP_054203203.1  intraflagellar transport protein 122 homolog isoform X8

  9. XM_054347229.1 → XP_054203204.1  intraflagellar transport protein 122 homolog isoform X9

  10. XM_054347230.1 → XP_054203205.1  intraflagellar transport protein 122 homolog isoform X10

  11. XM_054347226.1 → XP_054203201.1  intraflagellar transport protein 122 homolog isoform X7

  12. XM_054347231.1 → XP_054203206.1  intraflagellar transport protein 122 homolog isoform X11

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HBG6.2 GenPept UniProtKB/Swiss-Prot:Q9HBG6

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