ltk leukocyte receptor tyrosine kinase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ltkprovided by ZNC
Official Full Name: leukocyte receptor tyrosine kinaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030616-115
See related: Ensembl:ENSDARG00000042861 AllianceGenome:ZFIN:ZDB-GENE-030616-115
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ALK; TYK1; si:dz107o16.1
Summary: Predicted to enable transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within several processes, including iridophore differentiation; melanocyte migration; and pigment cell development. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including immature eye; iridoblast; neural crest; notochord; and pigment cell. Orthologous to several human genes including LTK (leukocyte receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 17

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (31397772..31483595, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (31381196..31466646, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Leukocyte Tyrosine Kinase (Ltk) Is the Mendelian Determinant of the Axolotl Melanoid Color Variant.
Title: Leukocyte Tyrosine Kinase (Ltk) Is the Mendelian Determinant of the Axolotl Melanoid Color Variant.
activation of ALK/LTK family receptors by small ALKAL proteins (FAM150, AUG) conserved in vertebrates
Title: ALKALs are in vivo ligands for ALK family receptor tyrosine kinases in the neural crest and derived cells.
Ltk specifically regulates iridophore establishment, proliferation and survival.
Title: Zebrafish Leucocyte tyrosine kinase controls iridophore establishment, proliferation and survival.
discovered a novel signalling pathway in neural crest cell development and demonstrated fate specification of iridophores as the first identified role for Ltk
Title: Leukocyte tyrosine kinase functions in pigment cell development.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within developmental pigmentation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within developmental pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in developmental pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within iridophore differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in iridophore differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within maintenance of cell number	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within melanocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within melanocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pigment cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pigment cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of developmental pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of developmental pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tyrosine-protein kinase receptor; leukocyte tyrosine kinase receptor

Names: alk-1; anaplastic lymphoma kinase; anaplastic lymphoma kinase 1; leukocyte tyrosine kinase; mne; protein moonstone; protein shady; shd; shd(l)

NP_001006661.1

EC 2.7.10.1

XP_005158843.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001006660.1 → NP_001006661.1 tyrosine-protein kinase receptor precursor

See identical proteins and their annotated locations for NP_001006661.1

Status: PROVISIONAL

Source sequence(s)

EU380906

UniProtKB/Swiss-Prot

B0LVZ8, B1PCZ3, B1PHI5, F1QBU7, F1QVU0

Related

ENSDARP00000061546.6, ENSDART00000061547.7

Conserved Domains (5) summary

cd06263
Location:277 → 431

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

smart00192
Location:239 → 264

LDLa; Low-density lipoprotein receptor domain class A

cd05036
Location:928 → 1204

PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase

pfam00629
Location:277 → 431

MAM; MAM domain, meprin/A5/mu

pfam07714
Location:935 → 1202

Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007128.7 Reference GRCz11 Primary Assembly

Range

31397772..31483595 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005158786.4 → XP_005158843.1 leukocyte tyrosine kinase receptor isoform X1

UniProtKB/Swiss-Prot

B0LVZ8, B1PCZ3, B1PHI5, F1QBU7, F1QVU0

Related

ENSDARP00000062906.6, ENSDART00000062907.8

Conserved Domains (5) summary

cd06263
Location:277 → 431

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

smart00192
Location:239 → 264

LDLa; Low-density lipoprotein receptor domain class A

cd05036
Location:902 → 1178

PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase

pfam00629
Location:277 → 431

MAM; MAM domain, meprin/A5/mu

pfam07714
Location:909 → 1176

Pkinase_Tyr; Protein tyrosine kinase