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WWTR1 WW domain containing transcription regulator 1 [ Canis lupus familiaris (dog) ]

Gene ID: 609743, updated on 5-Mar-2024

Summary

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Official Symbol
WWTR1provided by VGNC
Official Full Name
WW domain containing transcription regulator 1provided by VGNC
Primary source
VGNC:VGNC:52910
See related
Ensembl:ENSCAFG00845024146
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 23
Exon count:
7
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 23 NC_051827.1 (44904503..45038166, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 23 NC_006605.4 (44141713..44274178, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 23 NC_049244.1 (44796227..44929932, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 23 NC_049283.1 (44492243..44625480, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 23 NC_049764.1 (44541043..44673939, complement)

Chromosome 23 - NC_051827.1Genomic Context describing neighboring genes Neighboring gene transmembrane 4 L six family member 1 Neighboring gene uncharacterized LOC111091986 Neighboring gene transmembrane 4 L six family member 4 Neighboring gene uncharacterized LOC119865418 Neighboring gene uncharacterized LOC111091987 Neighboring gene uncharacterized LOC119865417

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An evaluation of TAZ and YAP crosstalk with TGFβ signalling in canine osteosarcoma suggests involvement of hippo signalling in disease progression. Luu AK, et al. BMC Vet Res, 2018 Nov 26. PMID 30477496, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. levels of nuclear TFGbeta, TAZ, YAP or combinations of these markers, will associate with established markers of poor prognosis, metastatic disease and overall patient survival in canine osteosarcoma
    Title: An evaluation of TAZ and YAP crosstalk with TGFβ signalling in canine osteosarcoma suggests involvement of hippo signalling in disease progression.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in hippo signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
WW domain-containing transcription regulator protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051827.1 Reference ROS_Cfam_1.0

    Range
    44904503..45038166 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038432650.1 → XP_038288578.1  WW domain-containing transcription regulator protein 1

    UniProtKB/TrEMBL
    A0A8C0MSK4, A0A8I3PQN6, A0A8P0NAJ7
    Conserved Domains (1) summary
    smart00456
    Location:125 → 156
    WW; Domain with 2 conserved Trp (W) residues

  2. XM_038432651.1 → XP_038288579.1  WW domain-containing transcription regulator protein 1

    UniProtKB/TrEMBL
    A0A8C0MSK4, A0A8I3PQN6, A0A8P0NAJ7
    Related
    ENSCAFP00845033446.1, ENSCAFT00845042653.1
    Conserved Domains (1) summary
    smart00456
    Location:125 → 156
    WW; Domain with 2 conserved Trp (W) residues

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049283.1 Alternate UMICH_Zoey_3.1

    Range
    44492243..44625480 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038507947.1 → XP_038363875.1  WW domain-containing transcription regulator protein 1

    Conserved Domains (1) summary
    smart00456
    Location:125 → 156
    WW; Domain with 2 conserved Trp (W) residues

  2. XM_038507948.1 → XP_038363876.1  WW domain-containing transcription regulator protein 1

    Conserved Domains (1) summary
    smart00456
    Location:125 → 156
    WW; Domain with 2 conserved Trp (W) residues

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049764.1 Alternate UNSW_CanFamBas_1.0

    Range
    44541043..44673939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038635381.1 → XP_038491309.1  WW domain-containing transcription regulator protein 1

    Conserved Domains (1) summary
    smart00456
    Location:125 → 156
    WW; Domain with 2 conserved Trp (W) residues

  2. XM_038635382.1 → XP_038491310.1  WW domain-containing transcription regulator protein 1

    Conserved Domains (1) summary
    smart00456
    Location:125 → 156
    WW; Domain with 2 conserved Trp (W) residues

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049244.1 Alternate UU_Cfam_GSD_1.0

    Range
    44796227..44929932 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038571189.1 → XP_038427117.1  WW domain-containing transcription regulator protein 1

    UniProtKB/TrEMBL
    A0A8C0MSK4, A0A8I3PQN6, A0A8P0NAJ7
    Conserved Domains (1) summary
    smart00456
    Location:125 → 156
    WW; Domain with 2 conserved Trp (W) residues

  2. XM_038571190.1 → XP_038427118.1  WW domain-containing transcription regulator protein 1

    UniProtKB/TrEMBL
    A0A8C0MSK4, A0A8I3PQN6, A0A8P0NAJ7
    Conserved Domains (1) summary
    smart00456
    Location:125 → 156
    WW; Domain with 2 conserved Trp (W) residues

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006605.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    44141713..44274178 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_847454.6 → XP_852547.1  WW domain-containing transcription regulator protein 1

    UniProtKB/TrEMBL
    A0A8C0MSK4, A0A8I3PQN6, A0A8P0NAJ7
    Conserved Domains (1) summary
    smart00456
    Location:125 → 156
    WW; Domain with 2 conserved Trp (W) residues

  2. XM_038457082.1 → XP_038313010.1  WW domain-containing transcription regulator protein 1

    UniProtKB/TrEMBL
    A0A8C0MSK4, A0A8I3PQN6, A0A8P0NAJ7
    Conserved Domains (1) summary
    smart00456
    Location:125 → 156
    WW; Domain with 2 conserved Trp (W) residues
Nucleotide Protein
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