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TPH1 tryptophan hydroxylase 1 [ Canis lupus familiaris (dog) ]

Gene ID: 611956, updated on 5-Mar-2024

Summary

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Official Symbol
TPH1provided by VGNC
Official Full Name
tryptophan hydroxylase 1provided by VGNC
Primary source
VGNC:VGNC:47738
See related
Ensembl:ENSCAFG00845015143
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 21
Exon count:
11
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 21 NC_051825.1 (41651924..41675891, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 21 NC_006603.4 (40047325..40065811, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 21 NC_049242.1 (41211247..41229722, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 21 NC_049281.1 (40664759..40683241, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 21 NC_049762.1 (40872839..40891326, complement)

Chromosome 21 - NC_051825.1Genomic Context describing neighboring genes Neighboring gene secretion regulating guanine nucleotide exchange factor Neighboring gene tigger transposable element-derived protein 1-like Neighboring gene uncharacterized LOC119865024 Neighboring gene uncharacterized LOC102155748 Neighboring gene uncharacterized LOC119865026 Neighboring gene serum amyloid A like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identifying novel polymorphisms in the canine tryptophan hydroxylase 2 gene. Kaneko F, et al. J Vet Med Sci, 2008 Oct. PMID 18981671

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tryptophan 5-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in aromatic amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in serotonin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tryptophan 5-hydroxylase 1
NP_001184120.1
XP_038285440.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001197191.1 → NP_001184120.1  tryptophan 5-hydroxylase 1

    See identical proteins and their annotated locations for NP_001184120.1

    Status: PROVISIONAL

    Source sequence(s)
    AB379810
    UniProtKB/TrEMBL
    A0A8C0L237, A0A8C0TLT8, B6EY10
    Conserved Domains (1) summary
    TIGR01270
    Location:3 → 439
    Trp_5_monoox; tryptophan 5-monooxygenase, tetrameric

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051825.1 Reference ROS_Cfam_1.0

    Range
    41651924..41675891 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038429512.1 → XP_038285440.1  tryptophan 5-hydroxylase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0L237, A0A8C0TLT8, B6EY10
    Related
    ENSCAFP00845021300.1, ENSCAFT00845027067.1
    Conserved Domains (1) summary
    TIGR01270
    Location:3 → 439
    Trp_5_monoox; tryptophan 5-monooxygenase, tetrameric

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049281.1 Alternate UMICH_Zoey_3.1

    Range
    40664759..40683241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049762.1 Alternate UNSW_CanFamBas_1.0

    Range
    40872839..40891326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049242.1 Alternate UU_Cfam_GSD_1.0

    Range
    41211247..41229722 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006603.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    40047325..40065811 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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