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Tcn2 transcobalamin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64365, updated on 2-May-2024

Summary

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Official Symbol
Tcn2provided by RGD
Official Full Name
transcobalamin 2provided by RGD
Primary source
RGD:620681
See related
Ensembl:ENSRNOG00000004280 AllianceGenome:RGD:620681
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tc2; Tcn2p
Summary
Enables cobalamin binding activity. Predicted to be involved in cobalamin transport. Located in extracellular space. Human ortholog(s) of this gene implicated in Parkinson's disease; megaloblastic anemia; and transcobalamin II deficiency. Orthologous to human TCN2 (transcobalamin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 531.8), Lung (RPKM 287.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tcn2 in Genome Data Viewer
Location:
14q21
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (83036935..83052187, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (78813343..78828549, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (84173992..84189299, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 5 open reading frame 52 Neighboring gene dual specificity phosphatase 18 Neighboring gene solute carrier family 35, member E4 Neighboring gene pescadillo ribosomal biogenesis factor 1 Neighboring gene galactose-3-O-sulfotransferase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Vitamin B12-impaired metabolism produces apoptosis and Parkinson phenotype in rats expressing the transcobalamin-oleosin chimera in substantia nigra. Orozco-Barrios CE, et al. PLoS One, 2009 Dec 21. PMID 20027219, Free PMC Article
  2. A transcobalamin gene polymorphism and the risk of venous thrombosis. The BRATROS (Brazilian Thrombosis Study). Pereira AC, et al. Thromb Res, 2007. PMID 16530812
  3. Cobalamin (vitamin B12) binding, phylogeny, and synteny of human transcobalamin. Kalra S, et al. Arch Biochem Biophys, 2004 Nov 15. PMID 15488467
  4. Transfer of cobalamin from intrinsic factor to transcobalamin II. Brada N, et al. J Nutr Biochem, 2001 Apr. PMID 11287214
  5. Transcobalamin II and its cell surface receptor. Seetharam B, et al. Vitam Horm, 2000. PMID 10714245

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cargo receptor ligand activity IEA
Inferred from Electronic Annotation
more info
  
enables cargo receptor ligand activity ISO
Inferred from Sequence Orthology
more info
  
enables cobalamin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cobalamin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cobalamin binding IEA
Inferred from Electronic Annotation
more info
  
enables cobalamin binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cobalamin transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cobalamin transport IEA
Inferred from Electronic Annotation
more info
  
involved_in cobalamin transport ISO
Inferred from Sequence Orthology
more info
  
involved_in cobalamin transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cobalamin transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in cobalt ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transcobalamin-2
Names
TC II
TC-2
TCII
transcobalamin II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022534.2 → NP_071979.2  transcobalamin-2 precursor

    See identical proteins and their annotated locations for NP_071979.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/Swiss-Prot
    Q9R0D6
    UniProtKB/TrEMBL
    A6IKD4, G3V6K1
    Related
    ENSRNOP00000077856.1, ENSRNOT00000093962.1
    Conserved Domains (2) summary
    pfam01122
    Location:19 → 325
    Cobalamin_bind; Eukaryotic cobalamin-binding protein
    pfam14478
    Location:352 → 424
    DUF4430; Domain of unknown function (DUF4430)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    83036935..83052187 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006251366.4 → XP_006251428.1  transcobalamin-2 isoform X1

    See identical proteins and their annotated locations for XP_006251428.1

    UniProtKB/Swiss-Prot
    Q9R0D6
    UniProtKB/TrEMBL
    A6IKD4, G3V6K1
    Conserved Domains (2) summary
    pfam01122
    Location:19 → 325
    Cobalamin_bind; Eukaryotic cobalamin-binding protein
    pfam14478
    Location:352 → 424
    DUF4430; Domain of unknown function (DUF4430)

  2. XM_006251368.3 → XP_006251430.1  transcobalamin-2 isoform X1

    See identical proteins and their annotated locations for XP_006251430.1

    UniProtKB/Swiss-Prot
    Q9R0D6
    UniProtKB/TrEMBL
    A6IKD4, G3V6K1
    Conserved Domains (2) summary
    pfam01122
    Location:19 → 325
    Cobalamin_bind; Eukaryotic cobalamin-binding protein
    pfam14478
    Location:352 → 424
    DUF4430; Domain of unknown function (DUF4430)

  3. XM_006251370.5 → XP_006251432.1  transcobalamin-2 isoform X1

    See identical proteins and their annotated locations for XP_006251432.1

    UniProtKB/Swiss-Prot
    Q9R0D6
    UniProtKB/TrEMBL
    A6IKD4, G3V6K1
    Conserved Domains (2) summary
    pfam01122
    Location:19 → 325
    Cobalamin_bind; Eukaryotic cobalamin-binding protein
    pfam14478
    Location:352 → 424
    DUF4430; Domain of unknown function (DUF4430)

  4. XM_006251367.5 → XP_006251429.1  transcobalamin-2 isoform X1

    See identical proteins and their annotated locations for XP_006251429.1

    UniProtKB/Swiss-Prot
    Q9R0D6
    UniProtKB/TrEMBL
    A6IKD4, G3V6K1
    Related
    ENSRNOP00000005934.2
    Conserved Domains (2) summary
    pfam01122
    Location:19 → 325
    Cobalamin_bind; Eukaryotic cobalamin-binding protein
    pfam14478
    Location:352 → 424
    DUF4430; Domain of unknown function (DUF4430)

  5. XM_017599370.3 → XP_017454859.1  transcobalamin-2 isoform X1

    UniProtKB/Swiss-Prot
    Q9R0D6
    UniProtKB/TrEMBL
    A6IKD4, G3V6K1
    Conserved Domains (2) summary
    pfam01122
    Location:19 → 325
    Cobalamin_bind; Eukaryotic cobalamin-binding protein
    pfam14478
    Location:352 → 424
    DUF4430; Domain of unknown function (DUF4430)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R0D6.1 GenPept UniProtKB/Swiss-Prot:Q9R0D6

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