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SOX5 SRY-box transcription factor 5 [ Homo sapiens (human) ]

Gene ID: 6660, updated on 7-Apr-2024

Summary

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Official Symbol
SOX5provided by HGNC
Official Full Name
SRY-box transcription factor 5provided by HGNC
Primary source
HGNC:HGNC:11201
See related
Ensembl:ENSG00000134532 MIM:604975; AllianceGenome:HGNC:11201
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L-SOX5; LAMSHF; L-SOX5B; L-SOX5F
Summary
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 2.2), brain (RPKM 1.6) and 22 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
12p12.1
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (23529504..24562650, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (23401301..24433529, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (23682438..24715425, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6100 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:22778539-22779228 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:22852449-22852990 Neighboring gene long intergenic non-protein coding RNA 2955 Neighboring gene MPRA-validated peak1602 silencer Neighboring gene ethanolamine kinase 1 Neighboring gene ribosomal protein S27 pseudogene 22 Neighboring gene MPRA-validated peak1603 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:23178329-23179078 Neighboring gene VISTA enhancer hs1603 Neighboring gene MPRA-validated peak1605 silencer Neighboring gene Sharpr-MPRA regulatory region 9485 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:23627288-23627862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:23627863-23628437 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:23662216-23662400 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_26611 Neighboring gene NANOG hESC enhancer GRCh37_chr12:23695058-23695588 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:23738604-23739190 Neighboring gene uncharacterized LOC105369697 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:23793632-23794207 Neighboring gene Sharpr-MPRA regulatory region 8728 Neighboring gene NANOG hESC enhancer GRCh37_chr12:23909365-23909887 Neighboring gene MPRA-validated peak1610 silencer Neighboring gene MPRA-validated peak1611 silencer Neighboring gene MPRA-validated peak1613 silencer Neighboring gene Sharpr-MPRA regulatory region 3652 Neighboring gene Sharpr-MPRA regulatory region 12792 Neighboring gene VISTA enhancer hs895 Neighboring gene MPRA-validated peak1614 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4290 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:24369389-24370015 Neighboring gene Sharpr-MPRA regulatory region 6359 Neighboring gene SOX5 antisense RNA 1 Neighboring gene microRNA 920 Neighboring gene NANOG hESC enhancer GRCh37_chr12:24744672-24745173 Neighboring gene uncharacterized LOC105369698 Neighboring gene long intergenic non-protein coding RNA 477 Neighboring gene lysine rich nucleolar protein 1 pseudogene 1 Neighboring gene ribosomal protein L21 pseudogene 102

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. SOX5 promotes cell growth and migration through modulating the DNMT1/p21 pathway in bladder cancer. Wu L, et al. Acta Biochim Biophys Sin (Shanghai), 2022 Jun 25. PMID 35880568, Free PMC Article
  2. Clinical spectrum and follow-up in six individuals with Lamb-Shaffer syndrome (SOX5). Innella G, et al. Am J Med Genet A, 2021 Feb. PMID 33296143
  3. Widening of the genetic and clinical spectrum of Lamb-Shaffer syndrome, a neurodevelopmental disorder due to SOX5 haploinsufficiency. Zawerton A, et al. Genet Med, 2020 Mar. PMID 31578471, Free PMC Article
  4. Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain. Suri P, et al. PLoS Genet, 2018 Sep. PMID 30261039, Free PMC Article
  5. SOX5 promotes epithelial-mesenchymal transition in osteosarcoma via regulation of Snail. Zhang D, et al. J BUON, 2017 Jan-Feb. PMID 28365963

See all (101) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lamb-Shaffer syndrome: 20 Spanish patients and literature review expands the view of neurodevelopmental disorders caused by SOX5 haploinsufficiency.
    Title: Lamb-Shaffer syndrome: 20 Spanish patients and literature review expands the view of neurodevelopmental disorders caused by SOX5 haploinsufficiency.
  2. EGR1/LINC00839/SOX5 axis modulates migration, invasion and Gemcitabine resistance of bladder cancer cells.
    Title: EGR1/LINC00839/SOX5 axis modulates migration, invasion and Gemcitabine resistance of bladder cancer cells.
  3. circ-LDLRAD3 Knockdown Reduces Cisplatin Chemoresistance and Inhibits the Development of Gastric Cancer with Cisplatin Resistance through miR-588 Enrichment-Mediated SOX5 Inhibition.
    Title: circ-LDLRAD3 Knockdown Reduces Cisplatin Chemoresistance and Inhibits the Development of Gastric Cancer with Cisplatin Resistance through miR-588 Enrichment-Mediated SOX5 Inhibition.
  4. SOX5 promotes cell growth and migration through modulating the DNMT1/p21 pathway in bladder cancer.
    Title: SOX5 promotes cell growth and migration through modulating the DNMT1/p21 pathway in bladder cancer.
  5. LINC00520 up-regulates SOX5 to promote cell proliferation and invasion by miR-4516 in human hepatocellular carcinoma.
    Title: LINC00520 up-regulates SOX5 to promote cell proliferation and invasion by miR-4516 in human hepatocellular carcinoma.
  6. miR-23a-3p regulated by LncRNA SNHG5 suppresses the chondrogenic differentiation of human adipose-derived stem cells via targeting SOX6/SOX5.
    Title: miR-23a-3p regulated by LncRNA SNHG5 suppresses the chondrogenic differentiation of human adipose-derived stem cells via targeting SOX6/SOX5.
  7. LncRNA UCC promotes epithelial-mesenchymal transition via the miR-143-3p/SOX5 axis in non-small-cell lung cancer.
    Title: LncRNA UCC promotes epithelial-mesenchymal transition via the miR-143-3p/SOX5 axis in non-small-cell lung cancer.
  8. Clinical spectrum and follow-up in six individuals with Lamb-Shaffer syndrome (SOX5).
    Title: Clinical spectrum and follow-up in six individuals with Lamb-Shaffer syndrome (SOX5).
  9. Serum levels of miRNA-21-5p in vitiligo patients and effects of miRNA-21-5p on SOX5, beta-catenin, CDK2 and MITF protein expression in normal human melanocytes.
    Title: Serum levels of miRNA-21-5p in vitiligo patients and effects of miRNA-21-5p on SOX5, beta-catenin, CDK2 and MITF protein expression in normal human melanocytes.
  10. High expression levels and localization of Sox5 in dilated cardiomyopathy.
    Title: High expression levels and localization of Sox5 in dilated cardiomyopathy.
Submit: New GeneRIF Correction See all GeneRIFs (61)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Lamb-Shaffer syndrome
MedGen: C4225202 OMIM: 616803 GeneReviews: Not available
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Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2016-08-19)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2016-08-19)

ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia.
EBI GWAS Catalog
A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.
EBI GWAS Catalog
Genome-wide association of lipid-lowering response to statins in combined study populations.
EBI GWAS Catalog
Genome-wide association study of PR interval.
EBI GWAS Catalog
Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03).
EBI GWAS Catalog
Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs.
EBI GWAS Catalog
Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC35153

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in asymmetric neuroblast division IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cartilage condensation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cartilage development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to transforming growth factor beta stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chondrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cartilage development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of chondrocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of chondrocyte differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of mesenchymal stem cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin ISA
Inferred from Sequence Alignment
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transcription factor SOX-5
Names
SRY (sex determining region Y)-box 5
SRY-box 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029612.2 RefSeqGene

    Range
    617777..1037943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001261414.3 → NP_001248343.1  transcription factor SOX-5 isoform d

    See identical proteins and their annotated locations for NP_001248343.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks an alternate in-frame segment compared to variant 1. The resulting isoform (d) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a.
    Source sequence(s)
    AB081589, AC087244, BC060773, BM988193, BX098902, DA343699
    Consensus CDS
    CCDS58216.1
    UniProtKB/Swiss-Prot
    P35711
    Related
    ENSP00000493866.1, ENST00000646273.1
    Conserved Domains (1) summary
    cd01388
    Location:434 → 505
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

  2. NM_001261415.3 → NP_001248344.1  transcription factor SOX-5 isoform e

    See identical proteins and their annotated locations for NP_001248344.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate first exon compared to variant 1. The resulting isoform (e) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AB081589, AC087244, AK303970, BM988193, BX098902
    Consensus CDS
    CCDS58217.1
    UniProtKB/Swiss-Prot
    P35711
    Related
    ENSP00000443520.1, ENST00000545921.5
    Conserved Domains (1) summary
    cd01388
    Location:545 → 616
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

  3. NM_001330785.2 → NP_001317714.1  transcription factor SOX-5 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (f) is shorter but has the same N- and C-termini compared to isoform a.
    Source sequence(s)
    AB081588, AC087244, BM988193, BX098902, DR003434
    Consensus CDS
    CCDS81672.1
    UniProtKB/TrEMBL
    F5H0I3
    Related
    ENSP00000439832.1, ENST00000537393.5
    Conserved Domains (1) summary
    cd01388
    Location:520 → 591
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

  4. NM_006940.6 → NP_008871.3  transcription factor SOX-5 isoform a

    See identical proteins and their annotated locations for NP_008871.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a, also called L-SOX5A).
    Source sequence(s)
    AB081589, AC087244, BM988193, BX098902
    Consensus CDS
    CCDS8699.1
    UniProtKB/Swiss-Prot
    B7Z8V0, F5H5B0, P35711, Q86UK8, Q8J017, Q8J018, Q8J019, Q8J020, Q8N1D9, Q8N7E0, Q8TEA4
    Related
    ENSP00000398273.2, ENST00000451604.7
    Conserved Domains (1) summary
    cd01388
    Location:555 → 626
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

  5. NM_152989.5 → NP_694534.1  transcription factor SOX-5 isoform b

    See identical proteins and their annotated locations for NP_694534.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b, also called L-SOX5B) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AB081588, AC087244, BC060773, BM988193, BX098902, DA343699
    UniProtKB/TrEMBL
    T2CYZ2
    Conserved Domains (1) summary
    cd01388
    Location:542 → 613
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

  6. NM_178010.4 → NP_821078.1  transcription factor SOX-5 isoform c

    See identical proteins and their annotated locations for NP_821078.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate first exon in place of much of the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AB081589, AC087244, AK098610, BM988193, BX098902
    Consensus CDS
    CCDS41761.1
    UniProtKB/TrEMBL
    Q53EV3
    Related
    ENSP00000379328.2, ENST00000396007.6
    Conserved Domains (1) summary
    cd01388
    Location:169 → 240
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    23529504..24562650 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449159.2 → XP_024304927.1  transcription factor SOX-5 isoform X10

    Conserved Domains (1) summary
    cd01388
    Location:543 → 614
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

  2. XM_024449158.2 → XP_024304926.1  transcription factor SOX-5 isoform X10

    Conserved Domains (1) summary
    cd01388
    Location:543 → 614
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

  3. XM_047429458.1 → XP_047285414.1  transcription factor SOX-5 isoform X10

  4. XM_017019891.2 → XP_016875380.1  transcription factor SOX-5 isoform X10

    Conserved Domains (1) summary
    cd01388
    Location:543 → 614
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

  5. XM_047429461.1 → XP_047285417.1  transcription factor SOX-5 isoform X10

  6. XM_017019892.2 → XP_016875381.1  transcription factor SOX-5 isoform X10

    Conserved Domains (1) summary
    cd01388
    Location:543 → 614
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

  7. XM_047429457.1 → XP_047285413.1  transcription factor SOX-5 isoform X10

  8. XM_024449157.2 → XP_024304925.1  transcription factor SOX-5 isoform X10

    Conserved Domains (1) summary
    cd01388
    Location:543 → 614
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

  9. XM_017019893.2 → XP_016875382.1  transcription factor SOX-5 isoform X10

    Conserved Domains (1) summary
    cd01388
    Location:543 → 614
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

  10. XM_024449154.2 → XP_024304922.1  transcription factor SOX-5 isoform X10

    Conserved Domains (1) summary
    cd01388
    Location:543 → 614
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

  11. XM_011520835.3 → XP_011519137.1  transcription factor SOX-5 isoform X10

    See identical proteins and their annotated locations for XP_011519137.1

    Conserved Domains (1) summary
    cd01388
    Location:543 → 614
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

  12. XM_017019890.2 → XP_016875379.1  transcription factor SOX-5 isoform X10

    Conserved Domains (1) summary
    cd01388
    Location:543 → 614
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

  13. XM_047429459.1 → XP_047285415.1  transcription factor SOX-5 isoform X10

  14. XM_024449153.2 → XP_024304921.1  transcription factor SOX-5 isoform X10

    Conserved Domains (1) summary
    cd01388
    Location:543 → 614
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

  15. XM_047429460.1 → XP_047285416.1  transcription factor SOX-5 isoform X10

  16. XM_024449150.2 → XP_024304918.1  transcription factor SOX-5 isoform X10

    Conserved Domains (1) summary
    cd01388
    Location:543 → 614
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

  17. XM_047429456.1 → XP_047285412.1  transcription factor SOX-5 isoform X10

  18. XM_024449151.2 → XP_024304919.1  transcription factor SOX-5 isoform X10

    Conserved Domains (1) summary
    cd01388
    Location:543 → 614
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

  19. XM_017019894.2 → XP_016875383.1  transcription factor SOX-5 isoform X10

    Conserved Domains (1) summary
    cd01388
    Location:543 → 614
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

  20. XM_047429462.1 → XP_047285418.1  transcription factor SOX-5 isoform X10

  21. XM_047429465.1 → XP_047285421.1  transcription factor SOX-5 isoform X13

    Related
    ENSP00000515823.1, ENST00000704299.1

  22. XM_047429464.1 → XP_047285420.1  transcription factor SOX-5 isoform X12

  23. XM_011520833.3 → XP_011519135.1  transcription factor SOX-5 isoform X7

    See identical proteins and their annotated locations for XP_011519135.1

    Conserved Domains (1) summary
    cd01388
    Location:546 → 617
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

  24. XM_047429455.1 → XP_047285411.1  transcription factor SOX-5 isoform X9

  25. XM_047429454.1 → XP_047285410.1  transcription factor SOX-5 isoform X8

  26. XM_047429453.1 → XP_047285409.1  transcription factor SOX-5 isoform X6

  27. XM_047429452.1 → XP_047285408.1  transcription factor SOX-5 isoform X5

  28. XM_017019889.2 → XP_016875378.1  transcription factor SOX-5 isoform X4

  29. XM_017019888.2 → XP_016875377.1  transcription factor SOX-5 isoform X3

  30. XM_047429451.1 → XP_047285407.1  transcription factor SOX-5 isoform X2

  31. XM_011520832.3 → XP_011519134.2  transcription factor SOX-5 isoform X1

  32. XM_047429463.1 → XP_047285419.1  transcription factor SOX-5 isoform X11

    UniProtKB/TrEMBL
    T2CYZ2

  33. XM_017019895.2 → XP_016875384.1  transcription factor SOX-5 isoform X10

    Conserved Domains (1) summary
    cd01388
    Location:543 → 614
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

  34. XM_011520837.3 → XP_011519139.1  transcription factor SOX-5 isoform X10

    See identical proteins and their annotated locations for XP_011519139.1

    Conserved Domains (1) summary
    cd01388
    Location:543 → 614
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

  35. XM_017019903.2 → XP_016875392.2  transcription factor SOX-5 isoform X15

    Related
    ENSP00000515822.1, ENST00000704298.1

  36. XM_017019902.2 → XP_016875391.2  transcription factor SOX-5 isoform X14

  37. XM_047429466.1 → XP_047285422.1  transcription factor SOX-5 isoform X16

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    23401301..24433529 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373061.1 → XP_054229036.1  transcription factor SOX-5 isoform X10

  2. XM_054373073.1 → XP_054229048.1  transcription factor SOX-5 isoform X10

  3. XM_054373070.1 → XP_054229045.1  transcription factor SOX-5 isoform X10

  4. XM_054373069.1 → XP_054229044.1  transcription factor SOX-5 isoform X10

  5. XM_054373064.1 → XP_054229039.1  transcription factor SOX-5 isoform X10

  6. XM_054373068.1 → XP_054229043.1  transcription factor SOX-5 isoform X10

  7. XM_054373075.1 → XP_054229050.1  transcription factor SOX-5 isoform X10

  8. XM_054373067.1 → XP_054229042.1  transcription factor SOX-5 isoform X10

  9. XM_054373071.1 → XP_054229046.1  transcription factor SOX-5 isoform X10

  10. XM_054373060.1 → XP_054229035.1  transcription factor SOX-5 isoform X10

  11. XM_054373072.1 → XP_054229047.1  transcription factor SOX-5 isoform X10

  12. XM_054373065.1 → XP_054229040.1  transcription factor SOX-5 isoform X10

  13. XM_054373074.1 → XP_054229049.1  transcription factor SOX-5 isoform X10

  14. XM_054373062.1 → XP_054229037.1  transcription factor SOX-5 isoform X10

  15. XM_054373066.1 → XP_054229041.1  transcription factor SOX-5 isoform X10

  16. XM_054373063.1 → XP_054229038.1  transcription factor SOX-5 isoform X10

  17. XM_054373076.1 → XP_054229051.1  transcription factor SOX-5 isoform X10

  18. XM_054373054.1 → XP_054229029.1  transcription factor SOX-5 isoform X4

  19. XM_054373053.1 → XP_054229028.1  transcription factor SOX-5 isoform X3

  20. XM_054373052.1 → XP_054229027.1  transcription factor SOX-5 isoform X2

  21. XM_054373081.1 → XP_054229056.1  transcription factor SOX-5 isoform X13

  22. XM_054373080.1 → XP_054229055.1  transcription factor SOX-5 isoform X12

  23. XM_054373057.1 → XP_054229032.1  transcription factor SOX-5 isoform X7

  24. XM_054373059.1 → XP_054229034.1  transcription factor SOX-5 isoform X9

  25. XM_054373058.1 → XP_054229033.1  transcription factor SOX-5 isoform X8

  26. XM_054373056.1 → XP_054229031.1  transcription factor SOX-5 isoform X6

  27. XM_054373055.1 → XP_054229030.1  transcription factor SOX-5 isoform X5

  28. XM_054373051.1 → XP_054229026.1  transcription factor SOX-5 isoform X1

  29. XM_054373079.1 → XP_054229054.1  transcription factor SOX-5 isoform X11

    UniProtKB/TrEMBL
    T2CYZ2

  30. XM_054373078.1 → XP_054229053.1  transcription factor SOX-5 isoform X10

  31. XM_054373077.1 → XP_054229052.1  transcription factor SOX-5 isoform X10

  32. XM_054373083.1 → XP_054229058.1  transcription factor SOX-5 isoform X15

  33. XM_054373082.1 → XP_054229057.1  transcription factor SOX-5 isoform X14

  34. XM_054373084.1 → XP_054229059.1  transcription factor SOX-5 isoform X16

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35711.3 GenPept UniProtKB/Swiss-Prot:P35711

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