gstp1.2 glutathione S-transferase pi 1.2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gstp1.2provided by ZNC
Official Full Name: glutathione S-transferase pi 1.2provided by ZNC
Primary source: ZFIN:ZDB-GENE-020806-4
See related: Ensembl:ENSDARG00000104068 AllianceGenome:ZFIN:ZDB-GENE-020806-4
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb356; gstp1; fa02f07; wu:fa02f07; wu:fj23a02; zgc:103706
Summary: Enables glutathione transferase activity. Acts upstream of or within cellular response to xenobiotic stimulus. Predicted to be active in cytosol. Is expressed in several structures, including digestive system; endoderm; pleuroperitoneal region; sensory system; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including brain disease (multiple); carcinoma (multiple); hematologic cancer (multiple); reproductive organ cancer (multiple); and respiratory system disease (multiple). Orthologous to human GSTP1 (glutathione S-transferase pi 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (3507305..3514045)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (3399999..3406739)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glutathione S-Transferase P Influences Redox Homeostasis and Response to Drugs that Induce the Unfolded Protein Response in Zebrafish.
Title: Glutathione S-Transferase P Influences Redox Homeostasis and Response to Drugs that Induce the Unfolded Protein Response in Zebrafish.
Purified GSTP1 displayed glutathione-conjugating activity toward 1-chloro-2,4-dinitrobenzene as a representative substrate. The enzymatic characteristics of the zebrafish GSTP1, including pH-dependency, effects of metal cations, and kinetic parameters, were studied.
Title: Identification and characterization of the zebrafish glutathione S-transferase Pi-1.

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General gene information

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Markers

fb09d09.x1 (e-PCR)
- UniSTS:202780

AW202842 (e-PCR)
- UniSTS:205727

fa02f07.s1 (e-PCR)
- UniSTS:202147

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutathione metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glutathione S-transferase P

Names: glutathione S-transferase pi 1

NP_571809.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131734.3 → NP_571809.1 glutathione S-transferase P

See identical proteins and their annotated locations for NP_571809.1

Status: VALIDATED

Source sequence(s)

AB194127, BI979167, CK361426

UniProtKB/TrEMBL

A0A0R4IS32, B3DGD4, Q9DDU5

Related

ENSDARP00000138645.1, ENSDART00000159326.2

Conserved Domains (3) summary

PTZ00057
Location:6 → 189

PTZ00057; glutathione s-transferase; Provisional

cd03210
Location:84 → 208

GST_C_Pi; C-terminal, alpha helical domain of Class Pi Glutathione S-transferases

cd03076
Location:3 → 76

GST_N_Pi; GST_N family, Class Pi subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...