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CPEB4 cytoplasmic polyadenylation element binding protein 4 [ Homo sapiens (human) ]

Gene ID: 80315, updated on 7-Apr-2024

Summary

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Official Symbol
CPEB4provided by HGNC
Official Full Name
cytoplasmic polyadenylation element binding protein 4provided by HGNC
Primary source
HGNC:HGNC:21747
See related
Ensembl:ENSG00000113742 MIM:610607; AllianceGenome:HGNC:21747
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPE-BP4; hCPEB-4
Summary
Enables RNA binding activity. Predicted to be involved in several processes, including cellular response to glucose starvation; negative regulation of cytoplasmic translation; and response to ischemia. Located in cytoplasm and nucleus. Biomarker of liver cirrhosis; portal hypertension; and primary biliary cholangitis. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal (RPKM 26.5), bone marrow (RPKM 18.8) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See CPEB4 in Genome Data Viewer
Location:
5q35.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (173888349..173961980)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (174428718..174502324)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (173315352..173388983)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901138 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:173198292-173199282 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:173204773-173205972 Neighboring gene uncharacterized LOC107986482 Neighboring gene NFE2L2 motif-containing MPRA enhancer 276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23665 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23666 Neighboring gene long intergenic non-protein coding RNA 1485 Neighboring gene Sharpr-MPRA regulatory region 2476 Neighboring gene CRISPRi-validated cis-regulatory element chr5.4552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23667 Neighboring gene Sharpr-MPRA regulatory region 12964 Neighboring gene CRISPRi-validated cis-regulatory element chr5.4558 Neighboring gene Sharpr-MPRA regulatory region 12084 Neighboring gene CRISPRi-validated cis-regulatory element chr5.4561 Neighboring gene CRISPRi-validated cis-regulatory element chr5.4562 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:173301919-173302077 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23668 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23669 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:173317123-173317624 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:173317625-173318124 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23670 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23671 Neighboring gene Sharpr-MPRA regulatory region 4386 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23672 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:173368663-173369301 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:173390440-173391639 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:173394847-173395510 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23673 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:173408357-173408858 Neighboring gene chromosome 5 open reading frame 47 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:173446513-173447102 Neighboring gene ribosomal protein L12 pseudogene 22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Antitumor T-cell function requires CPEB4-mediated adaptation to chronic endoplasmic reticulum stress. Fernández-Alfara M, et al. EMBO J, 2023 May 2. PMID 36919984, Free PMC Article
  2. Macrophage inflammation resolution requires CPEB4-directed offsetting of mRNA degradation. Suñer C, et al. Elife, 2022 Apr 20. PMID 35442882, Free PMC Article
  3. Targeting the cytoplasmic polyadenylation element-binding protein CPEB4 protects against diet-induced obesity and microbiome dysbiosis. Pell N, et al. Mol Metab, 2021 Dec. PMID 34774811, Free PMC Article
  4. [Effect of CPEB4 on Migration and Cycle of Chronic Myeloid Leukemia Cell]. Xu XY, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2020 Aug. PMID 32798388
  5. [Effect of CPEB4 on Proliferation and Apoptosis of Chronic Myeloid Leukemia Cells]. Xu XY, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2019 Dec. PMID 31839038

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Down-Regulation of CPEB4 Alleviates Preeclampsia through the Inhibition of Ferroptosis by PFKFB3.
    Title: Down-Regulation of CPEB4 Alleviates Preeclampsia through the Inhibition of Ferroptosis by PFKFB3.
  2. Antitumor T-cell function requires CPEB4-mediated adaptation to chronic endoplasmic reticulum stress.
    Title: Antitumor T-cell function requires CPEB4-mediated adaptation to chronic endoplasmic reticulum stress.
  3. Macrophage inflammation resolution requires CPEB4-directed offsetting of mRNA degradation.
    Title: Macrophage inflammation resolution requires CPEB4-directed offsetting of mRNA degradation.
  4. Targeting the cytoplasmic polyadenylation element-binding protein CPEB4 protects against diet-induced obesity and microbiome dysbiosis.
    Title: Targeting the cytoplasmic polyadenylation element-binding protein CPEB4 protects against diet-induced obesity and microbiome dysbiosis.
  5. Investigation of the expression levels of CPEB4, APC, TRIP13, EIF2S3, EIF4A1, IFNg, PIK3CA and CTNNB1 genes in different stage colorectal tumors
    Title: Investigation of the expression levels of CPEB4, APC, TRIP13, EIF2S3, EIF4A1, IFNg, PIK3CA and CTNNB1 genes in different stage colorectal tumors.
  6. CPEB4 Increases Expression of PFKFB3 to Induce Glycolysis and Activate Mouse and Human Hepatic Stellate Cells, Promoting Liver Fibrosis.
    Title: CPEB4 Increases Expression of PFKFB3 to Induce Glycolysis and Activate Mouse and Human Hepatic Stellate Cells, Promoting Liver Fibrosis.
  7. LncRNA EWSAT1 upregulates CPEB4 via miR-330-5p to promote cervical cancer development.
    Title: LncRNA EWSAT1 upregulates CPEB4 via miR-330-5p to promote cervical cancer development.
  8. Polyadenylation of mRNA as a novel regulatory mechanism of gene expression in temporal lobe epilepsy.
    Title: Polyadenylation of mRNA as a novel regulatory mechanism of gene expression in temporal lobe epilepsy.
  9. LncRNA RP11-361F15.2 promotes osteosarcoma tumorigenesis by inhibiting M2-Like polarization of tumor-associated macrophages of CPEB4.
    Title: LncRNA RP11-361F15.2 promotes osteosarcoma tumorigenesis by inhibiting M2-Like polarization of tumor-associated macrophages of CPEB4.
  10. Silencing lncRNA FOXD2-AS1 inhibits proliferation, migration, invasion and drug resistance of drug-resistant glioma cells and promotes their apoptosis via microRNA-98-5p/CPEB4 axis.
    Title: Silencing lncRNA FOXD2-AS1 inhibits proliferation, migration, invasion and drug resistance of drug-resistant glioma cells and promotes their apoptosis via microRNA-98-5p/CPEB4 axis.
Submit: New GeneRIF Correction See all GeneRIFs (36)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP.
EBI GWAS Catalog
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1673

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA regulatory element binding translation repressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation factor activity, RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to amino acid stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to decreased oxygen levels ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to glucose starvation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ionotropic glutamate receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to ischemia ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in growth cone IEA
Inferred from Electronic Annotation
more info
  
part_of messenger ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cytoplasmic polyadenylation element-binding protein 4
Names
CPE-binding protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308189.2 → NP_001295118.1  cytoplasmic polyadenylation element-binding protein 4 isoform b

    See identical proteins and their annotated locations for NP_001295118.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AB051460, AC093275, AI742270, BC143958, BQ061431, BU629646, BX538213, CR741268, DA803281, R64139
    Consensus CDS
    CCDS78086.1
    UniProtKB/TrEMBL
    E5RJM0
    Related
    ENSP00000334533.5, ENST00000334035.9
    Conserved Domains (3) summary
    pfam16366
    Location:638 → 699
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    cd12724
    Location:455 → 546
    RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:563 → 643
    RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

  2. NM_001308191.2 → NP_001295120.1  cytoplasmic polyadenylation element-binding protein 4 isoform c

    See identical proteins and their annotated locations for NP_001295120.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the central coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
    Source sequence(s)
    AB051460, AC093275, AI742270, BC143959, BQ061431, BU629646, BX538213, CR741268, DA803281, R64139
    Consensus CDS
    CCDS78087.1
    UniProtKB/TrEMBL
    B7ZLQ8, E5RJM0
    Related
    ENSP00000429092.1, ENST00000520867.5
    Conserved Domains (3) summary
    pfam16366
    Location:630 → 691
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    cd12724
    Location:447 → 538
    RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:555 → 635
    RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

  3. NM_001308192.2 → NP_001295121.1  cytoplasmic polyadenylation element-binding protein 4 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' terminal exon, resulting in an alternate 5' UTR and translation initiation at a downstream in-frame start codon, and it also lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (d) is shorter at the N-terminus and lacks an internal segment, compared to isoform a.
    Source sequence(s)
    AB051460, AC093275, AI742270, BC036899, BX401008, BX538213, CR741268, R64139
    Consensus CDS
    CCDS83043.1
    UniProtKB/TrEMBL
    A0A590UJI5, E5RFP2
    Related
    ENSP00000430345.1, ENST00000522336.5
    Conserved Domains (3) summary
    pfam16366
    Location:265 → 326
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    cd12724
    Location:82 → 173
    RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:190 → 270
    RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

  4. NM_001308193.2 → NP_001295122.1  cytoplasmic polyadenylation element-binding protein 4 isoform e

    See identical proteins and their annotated locations for NP_001295122.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate 5' terminal exon, resulting in an alternate 5' UTR and translation initiation at a downstream in-frame start codon, and it also lacks two alternate in-frame exons in the central coding region, compared to variant 1. The encoded isoform (e) is shorter at the N-terminus and lacks an internal segment, compared to isoform a.
    Source sequence(s)
    AB051460, AC093275, AI742270, BC036899, BX401008, BX538213, CR741268, R64139
    Consensus CDS
    CCDS83044.1
    UniProtKB/TrEMBL
    A0A590UJI5
    Related
    ENSP00000427990.1, ENST00000517880.1
    Conserved Domains (3) summary
    cd12724
    Location:65 → 156
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:173 → 253
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:248 → 309
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

  5. NM_030627.4 → NP_085130.2  cytoplasmic polyadenylation element-binding protein 4 isoform a

    See identical proteins and their annotated locations for NP_085130.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AB051460, AC093275, AI742270, BC117150, BQ061431, BU629646, BX538213, CR741268, DA803281, R64139
    Consensus CDS
    CCDS4390.1
    UniProtKB/Swiss-Prot
    B7ZLQ7, Q17RY0, Q7Z310, Q8N405, Q9C0J0
    UniProtKB/TrEMBL
    E5RJM0
    Related
    ENSP00000265085.5, ENST00000265085.10
    Conserved Domains (3) summary
    pfam16366
    Location:655 → 716
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    cd12724
    Location:472 → 563
    RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:580 → 660
    RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    173888349..173961980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    174428718..174502324
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q17RY0.1 GenPept UniProtKB/Swiss-Prot:Q17RY0

Gene LinkOut

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