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PF3D7_1337200 1-deoxy-D-xylulose 5-phosphate synthase [ Plasmodium falciparum 3D7 ]

Gene ID: 813741, updated on 16-Oct-2023

Summary

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Gene symbol
PF3D7_1337200
Gene description
1-deoxy-D-xylulose 5-phosphate synthase
Locus tag
PF3D7_1337200
Gene type
protein coding
RNA name
1-deoxy-D-xylulose 5-phosphate synthase
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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Genomic context

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Location:
chromosome: 13
Exon count:
1
Sequence:
Chromosome: 13; NC_004331.3 (1497877..1501494)

Chromosome 13 - NC_004331.3Genomic Context describing neighboring genes Neighboring gene mitochondrial intermediate peptidase, putative Neighboring gene protein kinase 6 Neighboring gene exoribonuclease, putative Neighboring gene zinc finger protein, putative

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004331.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mechanistic binding insights for 1-deoxy-D-Xylulose-5-Phosphate synthase, the enzyme catalyzing the first reaction of isoprenoid biosynthesis in the malaria-causing protists, Plasmodium falciparum and Plasmodium vivax. Battistini MR, et al. Protein Expr Purif, 2016 Apr. PMID 26699947, Free PMC Article
  2. Integrative proteomics and bioinformatic prediction enable a high-confidence apicoplast proteome in malaria parasites. Boucher MJ, et al. PLoS Biol, 2018 Sep. PMID 30212465, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Enzyme adheres to a random sequential mechanism with respect to binding of both substrates: pyruvate and D-glyceraldehyde-3-phosphate.
    Title: Mechanistic binding insights for 1-deoxy-D-Xylulose-5-Phosphate synthase, the enzyme catalyzing the first reaction of isoprenoid biosynthesis in the malaria-causing protists, Plasmodium falciparum and Plasmodium vivax.
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Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by GeneDB

Component Evidence Code Pubs
located_in apicoplast HDA PubMed 

General protein information

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Preferred Names
1-deoxy-D-xylulose 5-phosphate synthase
XP_001350100.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004331.3 Reference assembly

    Range
    1497877..1501494
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001350064.1 → XP_001350100.1  1-deoxy-D-xylulose 5-phosphate synthase [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001350100.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A024W2C7, O96694, Q8IDW0, W7KAR5
    Conserved Domains (1) summary
    PRK05444
    Location:417 → 1200
    PRK05444; 1-deoxy-D-xylulose-5-phosphate synthase; Provisional
Nucleotide Protein
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Gene LinkOut

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Molecular Biology Databases