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Tnk1 tyrosine kinase, non-receptor, 1 [ Mus musculus (house mouse) ]

Gene ID: 83813, updated on 11-Apr-2024

Summary

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Official Symbol
Tnk1provided by MGI
Official Full Name
tyrosine kinase, non-receptor, 1provided by MGI
Primary source
MGI:MGI:1930958
See related
Ensembl:ENSMUSG00000001583 AllianceGenome:MGI:1930958
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kos1; Tnk1a; Tnk1b
Summary
Enables ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Involved in negative regulation of Ras protein signal transduction; negative regulation of cell growth; and protein autophosphorylation. Located in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; pituitary gland; respiratory system; and thymus. Orthologous to human TNK1 (tyrosine kinase non receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 21.8), large intestine adult (RPKM 15.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tnk1 in Genome Data Viewer
Location:
11 B3; 11 42.9 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69741389..69749556, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69850563..69858730, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene neuroligin 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69651958-69652141 Neighboring gene transmembrane protein 256 Neighboring gene phospholipid scramblase 3 Neighboring gene predicted gene, 32708 Neighboring gene STARR-seq mESC enhancer starr_29868 Neighboring gene transmembrane protein 95

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A Novel Putative Role of TNK1 in Atherosclerotic Inflammation Implicating the Tyk2/STAT1 Pathway. Bao MH, et al. Mediators Inflamm, 2020. PMID 32694928, Free PMC Article
  2. Functional characterization of the murine Tnk1 promoter. Hoare S, et al. Gene, 2009 Sep 1. PMID 19481140, Free PMC Article
  3. Tnk1/Kos1 knockout mice develop spontaneous tumors. Hoare S, et al. Cancer Res, 2008 Nov 1. PMID 18974114
  4. Thirty-eight-negative kinase 1 mediates trauma-induced intestinal injury and multi-organ failure. Armacki M, et al. J Clin Invest, 2018 Nov 1. PMID 30320600, Free PMC Article
  5. Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling. Hoare K, et al. Oncogene, 2003 Jun 5. PMID 12789265

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Novel Putative Role of TNK1 in Atherosclerotic Inflammation Implicating the Tyk2/STAT1 Pathway.
    Title: A Novel Putative Role of TNK1 in Atherosclerotic Inflammation Implicating the Tyk2/STAT1 Pathway.
  2. TNK1 was found to be deregulated in the gut in murine and porcine trauma models and human inflammatory bowel disease. Thus, TNK1 might be a target during MODS to prevent damage in several organs, notably the gut.
    Title: Thirty-eight-negative kinase 1 mediates trauma-induced intestinal injury and multi-organ failure.
  3. The activated TNK1 potentiates JAK-STAT signaling through dual phosphorylation of STAT1 at tyrosine 701 and serine 727 amino acid positions.
    Title: Novel antiviral host factor, TNK1, regulates IFN signaling through serine phosphorylation of STAT1.
  4. cellular stress reverses the repression of Tnk1/Kos1 and induces its expression through increased high affinity interactions between nuclear proteins Sp1, Sp3, AP2 and MED1 for the m-Tnk1 promoter
    Title: Functional characterization of the murine Tnk1 promoter.
  5. Tnk1/Kos1 is a tumor suppressor that functions to down-regulate Ras activity
    Title: Tnk1/Kos1 knockout mice develop spontaneous tumors.
  6. data support a negative regulatory role for Kos1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity
    Title: Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
non-receptor tyrosine-protein kinase TNK1
Names
kinase of embryonic stem cells
non-receptor tyrosine kinase
NP_114086.3
XP_006534617.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031880.3 → NP_114086.3  non-receptor tyrosine-protein kinase TNK1

    See identical proteins and their annotated locations for NP_114086.3

    Status: VALIDATED

    Source sequence(s)
    AK033440, AK167292, BB676903, BX528991
    Consensus CDS
    CCDS24917.1
    UniProtKB/Swiss-Prot
    Q8CCC4, Q8K0X9, Q91V11, Q99ML2
    UniProtKB/TrEMBL
    Q5F2B4
    Related
    ENSMUSP00000001626.4, ENSMUST00000001626.10
    Conserved Domains (4) summary
    cd09539
    Location:16 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    cl17036
    Location:395 → 436
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:120 → 380
    PKc_like; Protein Kinases, catalytic domain
    cl21463
    Location:624 → 663
    UBA_like_SF; UBA domain-like superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    69741389..69749556 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534554.3 → XP_006534617.1  non-receptor tyrosine-protein kinase TNK1 isoform X1

    See identical proteins and their annotated locations for XP_006534617.1

    UniProtKB/Swiss-Prot
    Q8CCC4, Q8K0X9, Q91V11, Q99ML2
    UniProtKB/TrEMBL
    Q5F2B4
    Related
    ENSMUSP00000104268.2, ENSMUST00000108628.8
    Conserved Domains (4) summary
    cd09539
    Location:16 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    cl17036
    Location:395 → 436
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:120 → 380
    PKc_like; Protein Kinases, catalytic domain
    cl21463
    Location:624 → 663
    UBA_like_SF; UBA domain-like superfamily

RNA

  1. XR_879778.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99ML2.2 GenPept UniProtKB/Swiss-Prot:Q99ML2

Gene LinkOut

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