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Folh1 folate hydrolase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 85309, updated on 3-Apr-2024

Summary

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Official Symbol
Folh1provided by RGD
Official Full Name
folate hydrolase 1provided by RGD
Primary source
RGD:70963
See related
Ensembl:ENSRNOG00000013770 AllianceGenome:RGD:70963
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Naalad
Summary
Predicted to enable Ac-Asp-Glu binding activity; exopeptidase activity; and tetrahydrofolyl-poly(glutamate) polymer binding activity. Involved in positive regulation of apoptotic process and proteolysis. Predicted to be located in cell surface. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Orthologous to several human genes including FOLH1 (folate hydrolase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 251.5) and Brain (RPKM 88.9) See more
Orthologs
human mouse all
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Genomic context

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See Folh1 in Genome Data Viewer
Location:
1q32
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (149828286..149914313, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (140428101..140501563, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (150323768..150395415, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 14 subfamily A member 261, pseudogene 1 Neighboring gene olfactory receptor family 14 subfamily C member 39 Neighboring gene twinkle protein, mitochondrial pseudogene Neighboring gene vomeronasal 2 receptor, pseudogene 66 Neighboring gene vomeronasal 2 receptor, pseudogene 67

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Effects of N-acetylaspartylglutamate (NAAG) peptidase inhibition on release of glutamate and dopamine in prefrontal cortex and nucleus accumbens in phencyclidine model of schizophrenia. Zuo D, et al. J Biol Chem, 2012 Jun 22. PMID 22570482, Free PMC Article
  2. N-Acetylated alpha-linked acidic dipeptidase expressed in rat adipocytes is localized in the insulin-responsive glucose transporter (GLUT4) intracellular compartments and involved in the insulin-stimulated GLUT4 recruitment. Park SY, et al. Arch Biochem Biophys, 2004 Apr 1. PMID 15019832
  3. Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models. Ghadge GD, et al. Proc Natl Acad Sci U S A, 2003 Aug 5. PMID 12876198, Free PMC Article
  4. Isolation and expression of a rat brain cDNA encoding glutamate carboxypeptidase II. Luthi-Carter R, et al. Proc Natl Acad Sci U S A, 1998 Mar 17. PMID 9501243, Free PMC Article
  5. Molecular cloning of a peptidase against N-acetylaspartylglutamate from a rat hippocampal cDNA library. Bzdega T, et al. J Neurochem, 1997 Dec. PMID 9375657

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Folh1 gene plays an important role in folate and sulfur amino acid levels and affects glucose and lipid metabolism in the rat.
    Title: Dissecting the role of Folr1 and Folh1 genes in the pathogenesis of metabolic syndrome in spontaneously hypertensive rats.
  2. NAAG peptidase inhibition has a role in release of glutamate and dopamine in prefrontal cortex and nucleus accumbens in phencyclidine model of schizophrenia
    Title: Effects of N-acetylaspartylglutamate (NAAG) peptidase inhibition on release of glutamate and dopamine in prefrontal cortex and nucleus accumbens in phencyclidine model of schizophrenia.
  3. Tissues such as prostate and testes exhibit different GCPII expression levels among the species studied (human, rats, swine).
    Title: Tissue expression and enzymologic characterization of human prostate specific membrane antigen and its rat and pig orthologs.
  4. role of glutamate carboxypeptidase II inhibition in preventing programmed cell death in neurons exposed to high glucose; this neuroprotection is mediated through the mGluR3 receptor, most likely by increasing the extracellular NAAG concentration
    Title: Protection against glucose-induced neuronal death by NAAG and GCP II inhibition is regulated by mGluR3.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables Ac-Asp-Glu binding ISO
Inferred from Sequence Orthology
more info
  
enables carboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables carboxypeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables dipeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables dipeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallocarboxypeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables tetrahydrofolyl-poly(glutamate) polymer binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in folic acid-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within folic acid-containing compound metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glutamate carboxypeptidase 2
Names
FGCP
GCPII
N-acetylated alpha-linked acidic dipeptidase
N-acetylated-alpha-linked acidic dipeptidase I
NAALADase I
folylpoly-gamma-glutamate carboxypeptidase
glutamate carboxypeptidase II
mGCP
membrane glutamate carboxypeptidase
prostate-specific membrane antigen homolog
pteroylpoly-gamma-glutamate carboxypeptidase
NP_476533.2
XP_038948866.1
XP_063131972.1
XP_063131974.1
XP_063131977.1
XP_063131978.1
XP_063131979.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_057185.3 → NP_476533.2  glutamate carboxypeptidase 2

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    P70627, Q547B6
    UniProtKB/TrEMBL
    A6I5Y1, G3V7S0
    Related
    ENSRNOP00000018592.3, ENSRNOT00000018592.4
    Conserved Domains (4) summary
    cd02121
    Location:122 → 348
    PA_GCPII_like; Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to the peptidase ...
    cd08022
    Location:356 → 597
    M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
    pfam04253
    Location:629 → 749
    TFR_dimer; Transferrin receptor-like dimerization domain
    cl14876
    Location:60 → 117
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    149828286..149914313 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275902.1 → XP_063131972.1  glutamate carboxypeptidase 2 isoform X1

    UniProtKB/TrEMBL
    A6I5Y1, G3V7S0

  2. XM_063275904.1 → XP_063131974.1  glutamate carboxypeptidase 2 isoform X1

    UniProtKB/TrEMBL
    A6I5Y1, G3V7S0

  3. XM_039092938.2 → XP_038948866.1  glutamate carboxypeptidase 2 isoform X2

    UniProtKB/Swiss-Prot
    P70627, Q547B6
    Conserved Domains (3) summary
    cd02121
    Location:14 → 222
    PA_GCPII_like; Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to the peptidase ...
    cd08022
    Location:230 → 471
    M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
    pfam04253
    Location:503 → 623
    TFR_dimer; Transferrin receptor-like dimerization domain

  4. XM_063275909.1 → XP_063131979.1  glutamate carboxypeptidase 2 isoform X4

  5. XM_063275907.1 → XP_063131977.1  glutamate carboxypeptidase 2 isoform X3

  6. XM_063275908.1 → XP_063131978.1  glutamate carboxypeptidase 2 isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70627.1 GenPept UniProtKB/Swiss-Prot:P70627

Gene LinkOut

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