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CDC6 AAA family ATPase CDC6 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853244, updated on 17-May-2024

Summary

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Gene symbol
CDC6
Gene description
AAA family ATPase CDC6
Primary source
FungiDB:YJL194W
Locus tag
YJL194W
See related
SGD:S000003730; AllianceGenome:SGD:S000003730
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables several functions, including DNA replication origin binding activity; nucleoside-triphosphatase activity; and purine ribonucleoside triphosphate binding activity. Involved in G1/S transition of mitotic cell cycle; pre-replicative complex assembly involved in nuclear cell cycle DNA replication; and regulation of DNA-dependent DNA replication initiation. Located in cytoplasm and nucleus. Part of DNA replication preinitiation complex and nuclear pre-replicative complex. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 5. Orthologous to human CDC6 (cell division cycle 6). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See CDC6 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (69338..70879)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene putative ubiquitin-specific protease UBP12 Neighboring gene fatty acid elongase ELO1 Neighboring gene uncharacterized protein Neighboring gene Sop4p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization. Evrin C, et al. Nucleic Acids Res, 2013 Mar 1. PMID 23376927, Free PMC Article
  2. Trypanosome prereplication machinery contains a single functional orc1/cdc6 protein, which is typical of archaea. Godoy PD, et al. Eukaryot Cell, 2009 Oct. PMID 19717742, Free PMC Article
  3. The DNA-A component of a plant geminivirus (Indian mung bean yellow mosaic virus) replicates in budding yeast cells. Raghavan V, et al. J Virol, 2004 Mar. PMID 14963136, Free PMC Article
  4. Apoptosis-like yeast cell death in response to DNA damage and replication defects. Burhans WC, et al. Mutat Res, 2003 Nov 27. PMID 14643439
  5. Functions of sensor 1 and sensor 2 regions of Saccharomyces cerevisiae Cdc6p in vivo and in vitro. Takahashi N, et al. J Biol Chem, 2002 May 3. PMID 11827963

See all (198) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC.DNA.Cdc6.
    Title: A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6.
  2. Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae.
    Title: Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae.
  3. The structure of ORC-Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6.
    Title: The structure of ORC-Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6.
  4. DNA replication origins retain mobile licensing proteins.
    Title: DNA replication origins retain mobile licensing proteins.
  5. The global role of cyclin-specific phosphorylation has been resolved whereby a cyclin docking motif, LxF, that mediates binding of replication factor Cdc6 to mitotic cyclin has been uncovered.
    Title: Cyclin-Specific Docking Mechanisms Reveal the Complexity of M-CDK Function in the Cell Cycle.
  6. Repression of CDC6 and SLD2 during meiosis coincides with expression of shortened isoforms.
    Title: Transcriptional repression of CDC6 and SLD2 during meiosis is associated with production of short heterogeneous RNA isoforms.
  7. Cdc6 degradation triggered by Mck1 kinase was enhanced upon DNA damage.
    Title: Cdc6 degradation requires phosphodegron created by GSK-3 and Cdk1 for SCFCdc4 recognition in Saccharomyces cerevisiae.
  8. Cdc6 ATP hydrolysis is therefore required for Cdc6 disengagement from the pre-replicative complex after helicase loading to advance subsequent steps in helicase activation in vivo.
    Title: Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication.
  9. Data indicate that Cdt1-MCM2-7 complex activates ORC/Cdc6 ATP-hydrolysis to promote helicase loading.
    Title: An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer assembly.
  10. We propose that both CDK and Mck1 kinases are required for Cdc6 degradation to ensure a tight control of DNA replication.
    Title: A yeast GSK-3 kinase Mck1 promotes Cdc6 degradation to inhibit DNA re-replication.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA replication origin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cyclin-dependent protein serine/threonine kinase inhibitor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in MCM complex loading IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pre-replicative complex assembly involved in nuclear cell cycle DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pre-replicative complex assembly involved in nuclear cell cycle DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated DNA replication initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of DNA replication preinitiation complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm HDA PubMed 
part_of nuclear pre-replicative complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
AAA family ATPase CDC6
NP_012341.1
  • Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; dual role as a mitotic cyclin-dependent kinase inhibitor, that binds to and inhibits Cdc28p/Clb2p along with Sic1p, contributing to mitotic exit; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress; degraded in response to plasma membrane stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    69338..70879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181627.1 → NP_012341.1  TPA: AAA family ATPase CDC6 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012341.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVZ7, P09119
    UniProtKB/TrEMBL
    A0A6L0Z1P4, A6ZQE2, C7GS16, C8ZB26, G2WGI3, N1P1K7
    Conserved Domains (1) summary
    COG1474
    Location:77 → 508
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
5V8F_9.1
P09119.3

Gene LinkOut

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