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PRE10 proteasome core particle subunit alpha 7 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854544, updated on 13-Apr-2024

Summary

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Gene symbol
PRE10
Gene description
proteasome core particle subunit alpha 7
Primary source
SGD:S000005889
Locus tag
YOR362C
See related
AllianceGenome:SGD:S000005889
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables mRNA binding activity. Involved in proteasomal ubiquitin-independent protein catabolic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in proteasome storage granule. Part of proteasome core complex, alpha-subunit complex. Orthologous to human PSMA3 (proteasome 20S subunit alpha 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (1017880..1018746, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene 3',5'-cyclic-nucleotide phosphodiesterase PDE2 Neighboring gene translation initiation factor eIF3 core subunit b Neighboring gene oleate-activated transcription factor PIP2 Neighboring gene putative flavin adenine dinucleotide transporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of three phosphorylation sites in the alpha7 subunit of the yeast 20S proteasome in vivo using mass spectrometry. Iwafune Y, et al. Arch Biochem Biophys, 2004 Nov 1. PMID 15464721
  2. In vivo and in vitro phosphorylation of the alpha 7/PRS1 subunit of Saccharomyces cerevisiae 20 S proteasome: in vitro phosphorylation by protein kinase CK2 is absolutely dependent on polylysine. Pardo PS, et al. Arch Biochem Biophys, 1998 Jan 15. PMID 9448731
  3. Proteasome disassembly and downregulation is correlated with viability during stationary phase. Bajorek M, et al. Curr Biol, 2003 Jul 1. PMID 12842014
  4. Molecular cloning of the yeast proteasome PRS2 gene identical to the suppressor gene scl1+. Lee DH, et al. Biochem Int, 1991 Mar. PMID 1872882
  5. PRS3 encoding an essential subunit of yeast proteasomes homologous to mammalian proteasome subunit C5. Lee DH, et al. Biochem Biophys Res Commun, 1992 Jan 31. PMID 1734860

See all (111) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Proteasome core particle subunit alpha 7 is a binding partner for Ecm29.Ecm29 requires the phosphorylated tail of the proteasome subunit alpha7 for its association with proteasomes.
    Title: Phosphorylation of the C-terminal tail of proteasome subunit α7 is required for binding of the proteasome quality control factor Ecm29.
  2. the alpha7 N terminus of 20S proteasome has a role in core particle activation different from that of the alpha3 N terminus, and Fub1 antagonizes a specific function of the alpha7 N terminus
    Title: N-terminal α7 deletion of the proteasome 20S core particle substitutes for yeast PI31 function.
  3. Data show that proteasome subunits Rpt1, Rpt4, Rpn8, Rpn12, Pre6, and Pre10 are recruited to GAL10 rapidly upon galactose induction.
    Title: Similar temporal and spatial recruitment of native 19S and 20S proteasome subunits to transcriptionally active chromatin.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteasomal ubiquitin-independent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteasomal ubiquitin-independent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome core complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome core complex, alpha-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome core complex, alpha-subunit complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome core complex, alpha-subunit complex IEA
Inferred from Electronic Annotation
more info
  
located_in proteasome storage granule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
proteasome core particle subunit alpha 7
NP_015007.1
  • Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    1017880..1018746 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183782.1 → NP_015007.1  TPA: proteasome core particle subunit alpha 7 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015007.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W357, P21242
    UniProtKB/TrEMBL
    A0A6A5Q4M4, A6ZPJ2, B3LK19, C7GNQ6, C8ZHB0, G2WNM3, N1NXJ2
    Conserved Domains (1) summary
    cd03751
    Location:5 → 219
    proteasome_alpha_type_3; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
3JCO_G.1
3JCO_g.1
3JCP_G.1
3JCP_g.1
3UN4_F.1
3UN4_T.1
3UN8_F.1
3UN8_T.1
4G4S_G.1
4JSQ_F.1
4JSQ_T.1
4JSU_F.1
4JSU_T.1
4JT0_F.1
4JT0_T.1
4NNN_F.1
4NNN_T.1
4NNW_F.1
4NNW_T.1
4NO1_F.1
4NO1_T.1
4NO6_F.1
4NO6_T.1
4NO8_F.1
4NO8_T.1
4NO9_F.1
4NO9_T.1
4Q1S_F.1
4Q1S_T.1
4QBY_F.1
4QBY_T.1
4QLQ_F.1
4QLQ_T.1
4QLS_F.1
4QLS_T.1
4QLT_F.1
4QLT_T.1
4QLU_F.1
4QLU_T.1
4QLV_F.1
4QLV_T.1
4QUX_F.1
4QUX_T.1
4QUY_F.1
4QUY_T.1
4QV0_F.1
4QV0_T.1
4QV1_F.1
4QV1_T.1
4QV3_F.1
4QV3_T.1
4QV4_F.1
4QV4_T.1
4QV5_F.1
4QV5_T.1
4QV6_F.1
4QV6_T.1
4QV7_F.1
4QV7_T.1
4QV8_F.1
4QV8_T.1
4QV9_F.1
4QV9_T.1
4QVL_F.1
4QVL_T.1
4QVM_F.1
4QVM_T.1
4QVN_F.1
4QVN_T.1
4QVP_F.1
4QVP_T.1
4QVQ_F.1
4QVQ_T.1
4QVV_F.1
4QVV_T.1
4QVW_F.1
4QVW_T.1
4QVY_F.1
4QVY_T.1
4QW0_F.1
4QW0_T.1
4QW1_F.1
4QW1_T.1
4QW3_F.1
4QW3_T.1
4QW4_F.1
4QW4_T.1
4QW5_F.1
4QW5_T.1
4QW6_F.1
4QW6_T.1
4QW7_F.1
4QW7_T.1
4QWF_F.1
4QWF_T.1
4QWG_F.1
4QWG_T.1
4QWI_F.1
4QWI_T.1
4QWJ_F.1
4QWJ_T.1
4QWK_F.1
4QWK_T.1
4QWL_F.1
4QWL_T.1
4QWR_F.1
4QWR_T.1
4QWS_F.1
4QWS_T.1
4QWU_F.1
4QWU_T.1
4QWX_F.1
4QWX_T.1
4QXJ_F.1
4QXJ_T.1
4QZ0_F.1
4QZ0_T.1
4QZ1_F.1
4QZ1_T.1
4QZ2_F.1
4QZ2_T.1
4QZ3_F.1
4QZ3_T.1
4QZ4_F.1
4QZ4_T.1
4QZ5_F.1
4QZ5_T.1
4QZ6_F.1
4QZ6_T.1
4QZ7_F.1
4QZ7_T.1
4QZW_F.1
4QZW_T.1
4QZX_F.1
4QZX_T.1
4QZZ_F.1
4QZZ_T.1
4R00_F.1
4R00_T.1
4R02_F.1
4R02_T.1
4R17_F.1
4R17_T.1
4R18_F.1
4R18_T.1
4RUR_F.1
4RUR_T.1
4X6Z_G.1
4X6Z_U.1
4Y69_F.1
4Y69_T.1
4Y6A_F.1
4Y6A_T.1
4Y6V_F.1
4Y6V_T.1
4Y6Z_F.1
4Y6Z_T.1
4Y70_F.1
4Y70_T.1
4Y74_F.1
4Y74_T.1
4Y75_F.1
4Y75_T.1
4Y77_F.1
4Y77_T.1
4Y78_F.1
4Y78_T.1
4Y7W_F.1
4Y7W_T.1
4Y7X_F.1
4Y7X_T.1
4Y7Y_F.1
4Y7Y_T.1
4Y80_F.1
4Y80_T.1
4Y81_F.1
4Y81_T.1
4Y82_F.1
4Y82_T.1
4Y84_F.1
4Y84_T.1
4Y8G_F.1
4Y8G_T.1
4Y8H_F.1
4Y8H_T.1
4Y8I_F.1
4Y8I_T.1
4Y8J_F.1
4Y8J_T.1
4Y8K_F.1
4Y8K_T.1
4Y8L_F.1
4Y8L_T.1
4Y8M_F.1
4Y8M_T.1
4Y8N_F.1
4Y8N_T.1
4Y8O_F.1
4Y8O_T.1
4Y8P_F.1
4Y8P_T.1
4Y8Q_F.1
4Y8Q_T.1
4Y8R_F.1
4Y8R_T.1
4Y8S_F.1
4Y8S_T.1
4Y8T_F.1
4Y8T_T.1
4Y8U_F.1
4Y8U_T.1
4Y9Y_F.1
4Y9Y_T.1
4Y9Z_F.1
4Y9Z_T.1
4YA0_F.1
4YA0_T.1
4YA1_F.1
4YA1_T.1
4YA2_F.1
4YA2_T.1
4YA3_F.1
4YA3_T.1
4YA4_F.1
4YA4_T.1
4YA5_F.1
4YA5_T.1
4YA7_F.1
4YA7_T.1
4YA9_F.1
4YA9_T.1
4Z1L_F.1
4Z1L_T.1
5BOU_F.1
5BOU_T.1
5BXL_F.1
5BXL_T.1
5BXN_F.1
5BXN_T.1
5CGF_F.1
5CGF_T.1
5CGG_F.1
5CGG_T.1
5CGH_F.1
5CGH_T.1
5CGI_F.1
5CGI_T.1
5CZ4_F.1
5CZ4_T.1
5CZ5_F.1
5CZ5_T.1
5CZ6_F.1
5CZ6_T.1
5CZ7_F.1
5CZ7_T.1
5CZ8_F.1
5CZ8_T.1
5CZ9_F.1
5CZ9_T.1
5CZA_F.1
5CZA_T.1
5D0S_F.1
5D0S_T.1
5D0T_F.1
5D0T_T.1
5D0V_F.1
5D0V_T.1
5D0W_F.1
5D0W_T.1
5D0X_F.1
5D0X_T.1
5D0Z_F.1
5D0Z_T.1
5DKI_F.1
5DKI_T.1
5DKJ_F.1
5DKJ_T.1
5FG7_F.1
5FG7_T.1
5FG9_F.1
5FG9_T.1
5FGA_F.1
5FGA_T.1
5FGD_F.1
5FGD_T.1
5FGE_F.1
5FGE_T.1
5FGF_F.1
5FGF_T.1
5FGG_F.1
5FGG_T.1
5FGH_F.1
5FGH_T.1
5FGI_F.1
5FGI_T.1
5FHS_F.1
5FHS_T.1
5JHR_F.1
5JHR_T.1
5JHS_F.1
5JHS_T.1
5L52_F.1
5L52_T.1
5L54_F.1
5L54_T.1
5L55_F.1
5L55_T.1
5L5A_F.1
5L5A_T.1
5L5B_F.1
5L5B_T.1
5L5D_F.1
5L5D_T.1
5L5E_F.1
5L5E_T.1
5L5F_F.1
5L5F_T.1
5L5H_F.1
5L5H_T.1
5L5I_F.1
5L5I_T.1
5L5J_F.1
5L5J_T.1
5L5O_F.1
5L5O_T.1
5L5P_F.1
5L5P_T.1
5L5Q_F.1
5L5Q_T.1
5L5R_F.1
5L5R_T.1
5L5S_F.1
5L5S_T.1
5L5T_F.1
5L5T_T.1
5L5U_F.1
5L5U_T.1
5L5V_F.1
5L5V_T.1
5L5W_F.1
5L5W_T.1
5L5X_F.1
5L5X_T.1
5L5Y_F.1
5L5Y_T.1
5L5Z_F.1
5L5Z_T.1
5L60_F.1
5L60_T.1
5L61_F.1
5L61_T.1
5L62_F.1
5L62_T.1
5L63_F.1
5L63_T.1
5L64_F.1
5L64_T.1
5L65_F.1
5L65_T.1
5L66_F.1
5L66_T.1
5L67_F.1
5L67_T.1
5L68_F.1
5L68_T.1
5L69_F.1
5L69_T.1
5L6A_F.1
5L6A_T.1
5L6B_F.1
5L6B_T.1
5L6C_F.1
5L6C_T.1
5LAI_F.1
5LAI_T.1
5LAJ_F.1
5LAJ_T.1
5LTT_F.1
5LTT_T.1
5M2B_F.1
5M2B_T.1
5MP9_G.1
5MP9_g.1
5MPA_G.1
5MPA_g.1
5MPB_G.1
5MPB_g.1
5MPC_G.1
5MPC_g.1
5NIF_G.1
5NIF_U.1
5WVI_G.1
5WVI_k.1
5WVK_G.1
5WVK_k.1
6EF3_G.1
6G7F_F.1
6G7F_T.1
6G8M_F.1
6G8M_T.1
6G8N_F.1
6G8N_T.1
6GOP_F.1
6GOP_T.1
6H39_F.1
6H39_T.1
6HTB_F.1
6HTB_T.1
6HTC_F.1
6HTC_T.1
6HTD_F.1
6HTD_T.1
6HTP_F.1
6HTP_T.1
6HTR_F.1
6HTR_T.1
6HUB_F.1
6HUB_T.1
6HUC_F.1
6HUC_T.1
6HUQ_F.1
6HUQ_T.1
6HUU_F.1
6HUU_T.1
6HUV_F.1
6HUV_T.1
6HV3_F.1
6HV3_T.1
6HV4_F.1
6HV4_T.1
6HV5_F.1
6HV5_T.1
6HV7_F.1
6HV7_T.1
6HVA_F.1
6HVA_T.1
6HVR_F.1
6HVR_T.1
6HVS_F.1
6HVS_T.1
6HVT_F.1
6HVT_T.1
6HVU_F.1
6HVU_T.1
6HVV_F.1
6HVV_T.1
6HVW_F.1
6HVW_T.1
6HVX_F.1
6HVX_T.1
6HVY_F.1
6HVY_T.1
6HW0_F.1
6HW0_T.1
6HW3_F.1
6HW3_T.1
6HW4_F.1
6HW4_T.1
6HW5_F.1
6HW5_T.1
6HW6_F.1
6HW6_T.1
6HW7_F.1
6HW7_T.1
6HW8_F.1
6HW8_T.1
6HW9_F.1
6HW9_T.1
6HWA_F.1
6HWA_T.1
6HWB_F.1
6HWB_T.1
6HWC_F.1
6HWC_T.1
6HWD_F.1
6HWD_T.1
6HWE_F.1
6HWE_T.1
6HWF_F.1
6HWF_T.1
6J2C_G.1
6J2C_k.1
6J2N_G.1
6J2N_k.1
6J2Q_G.1
6J2Q_k.1
6J2X_G.1
6J2X_k.1
6J30_G.1
6J30_k.1
6ZOU_F.1
6ZOU_T.1
6ZP6_F.1
6ZP6_T.1
6ZP8_F.1
6ZP8_T.1
7LS5_G.1
7LS5_U.1
7LS6_G.1
7LSX_G.1
P21242.2

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