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TFB2 TFIIH/NER complex subunit TFB2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855981, updated on 13-Apr-2024

Summary

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Gene symbol
TFB2
Gene description
TFIIH/NER complex subunit TFB2
Primary source
SGD:S000006043
Locus tag
YPL122C
See related
AllianceGenome:SGD:S000006043
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables double-stranded DNA binding activity. Involved in nucleotide-excision repair; phosphorylation of RNA polymerase II C-terminal domain; and transcription by RNA polymerase II. Part of nucleotide-excision repair factor 3 complex; transcription factor TFIIH core complex; and transcription factor TFIIH holo complex. Orthologous to human GTF2H4 (general transcription factor IIH subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (319226..320767, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Spc29p Neighboring gene ribonuclease T2 Neighboring gene Mei5p Neighboring gene beclin 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure determination of the minimal complex between Tfb5 and Tfb2, two subunits of the yeast transcription/DNA-repair factor TFIIH: a retrospective study. Kainov DE, et al. Acta Crystallogr D Biol Crystallogr, 2010 Jul. PMID 20606254
  2. Tfb5 interacts with Tfb2 and facilitates nucleotide excision repair in yeast. Zhou Y, et al. Nucleic Acids Res, 2007. PMID 17215295, Free PMC Article
  3. Interacting partners of the Tfb2 subunit from yeast TFIIH. Kainov DE, et al. DNA Repair (Amst), 2010 Jan 2. PMID 19897425
  4. Nucleotide excision repair in yeast. Prakash S, et al. Mutat Res, 2000 Jun 30. PMID 10915862
  5. Ubiquitin ligase activity of TFIIH and the transcriptional response to DNA damage. Takagi Y, et al. Mol Cell, 2005 Apr 15. PMID 15837426

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Comparison of the two structures revealed that the N-terminal region of Tfb2C and (to a lesser extent) the C-terminal region of Tfb5 contributed to the crystal packing.
    Title: Structure determination of the minimal complex between Tfb5 and Tfb2, two subunits of the yeast transcription/DNA-repair factor TFIIH: a retrospective study.
  2. found that Tfb2 bridges the Ssl2 helicase and the nucleotide excision DNA repair pathway-specific Tfb5 subunit.
    Title: Interacting partners of the Tfb2 subunit from yeast TFIIH.
  3. Tfb5 was found to interact with the core TFIIH subunit Tfb2.
    Title: Tfb5 interacts with Tfb2 and facilitates nucleotide excision repair in yeast.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleotide-excision repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of nucleotide-excision repair factor 3 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIIH core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIH core complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIIH core complex IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIIH holo complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIH holo complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
TFIIH/NER complex subunit TFB2
NP_015203.1
  • Subunit of TFIIH and nucleotide excision repair factor 3 complexes; involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    319226..320767 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183936.1 → NP_015203.1  TPA: TFIIH/NER complex subunit TFB2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015203.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3P5, P87331, Q02939
    UniProtKB/TrEMBL
    A0A6A5Q2X3, A6ZWD0, B3LKV2, C7GJ76, C8ZIQ7, G2WP59, N1P1I8
    Conserved Domains (1) summary
    cl04289
    Location:9 → 510
    Tfb2; Transcription factor Tfb2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
7K01_2.1
7K04_2.1
7M2U_2.1
Q02939.1

Gene LinkOut

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