NA neuraminidase [Influenza A virus (A/Puerto Rico/8/1934(H1N1))] - Gene

Summary

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Gene symbol: NA
Gene description: neuraminidase
Locus tag: FLUAVs6gp1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Influenza A virus (A/Puerto Rico/8/1934(H1N1)) (strain: A/Puerto Rico/8/1934(H1N1))
Lineage: Viruses; ssRNA viruses; ssRNA negative-strand viruses; Orthomyxoviridae; Influenzavirus A
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Genomic context

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Location:: segment: 6

Sequence:: NC_002018.1 (21..1385)

NC_002018.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_002018.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein Disulfide Isomerase A3 Regulates Influenza Neuraminidase Activity and Influenza Burden in the Lung.
Title: Protein Disulfide Isomerase A3 Regulates Influenza Neuraminidase Activity and Influenza Burden in the Lung.
Antibodies directed towards neuraminidase restrict influenza virus replication in primary human bronchial epithelial cells.
Title: Antibodies directed towards neuraminidase restrict influenza virus replication in primary human bronchial epithelial cells.
Second sialic acid-binding site of influenza A virus neuraminidase: binding receptors for efficient release.
Title: Second sialic acid-binding site of influenza A virus neuraminidase: binding receptors for efficient release.
Comprehensive N-glycosylation analysis of the influenza A virus proteins HA and NA from adherent and suspension MDCK cells.
Title: Comprehensive N-glycosylation analysis of the influenza A virus proteins HA and NA from adherent and suspension MDCK cells.
Cross protection by inactivated recombinant influenza viruses containing chimeric hemagglutinin conjugates with a conserved neuraminidase or M2 ectodomain epitope.
Title: Cross protection by inactivated recombinant influenza viruses containing chimeric hemagglutinin conjugates with a conserved neuraminidase or M2 ectodomain epitope.
substitutions in HA (Asp225Gly or Gln226Arg) and compensatory mutation decreasing the charge of HA (Lys123Asn, Lys157Asn, Gly158Glu, Asn159Asp, or Lys212Met) altered viral receptor-binding specificity and restored the functional balance between HA and NA; (2) Phe35Leu substitution in the PA protein increased viral polymerase activity.
Title: [Mutations in Hemagglutinin and Polymerase Alter the Virulence of Pandemic A(H1N1) Influenza Virus].
we also demonstrate that NA[neuraminidase] mutations at residue Q136 can confer reduced zanamivir, peramivir or laninamivir susceptibility.
Title: Zanamivir-resistant influenza viruses with Q136K or Q136R neuraminidase residue mutations can arise during MDCK cell culture creating challenges for antiviral susceptibility monitoring.
FLUAV strains can counteract tetherin via their HA and NA proteins identifies these proteins as novel tetherin antagonists and indicates that HA/NA-dependent inactivation of innate defenses may contribute to the efficient spread of pandemic FLUAV.
Title: Tetherin Sensitivity of Influenza A Viruses Is Strain Specific: Role of Hemagglutinin and Neuraminidase.
study found six mutations in NA genes of five independent dextran sulfate resistant viruses and each resistant NA gene had two mutations; all mutations were from basic to acidic or neutral amino acids
Title: Dextran sulfate-resistant A/Puerto Rico/8/34 influenza virus is associated with the emergence of specific mutations in the neuraminidase glycoprotein.
Coexpression experiments revealed that apical targeting of HA and NA was accelerated by their coexpression.
Title: Influenza A virus hemagglutinin and neuraminidase mutually accelerate their apical targeting through clustering of lipid rafts.

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Pathways from PubChem

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General gene information

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Homology

Orthologs from OrthoDB

General protein information

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Preferred Names: neuraminidase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_002018.1 Reference assembly

Range

21..1385

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_040981.1 neuraminidase [Influenza A virus (A/Puerto Rico/8/1934(H1N1))]

See identical proteins and their annotated locations for NP_040981.1

Status: PROVISIONAL

UniProtKB/TrEMBL

A4ZNP9, R9WKX5, S5FSE2

Conserved Domains (1) summary

cd15483
Location:68 → 450

Influenza_NA; Sialidase or neuraminidase (EC 3.2.1.18) of Influenza viruses A and B