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PA polymerase PA [ Influenza A virus (A/Puerto Rico/8/1934(H1N1)) ]

Gene ID: 956535, updated on 18-Aug-2023

Summary

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Gene symbol
PA
Gene description
polymerase PA
Locus tag
FLUAVs3gp1
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Influenza A virus (A/Puerto Rico/8/1934(H1N1)) (strain: A/Puerto Rico/8/1934, serotype: H1N1)
Lineage
Viruses; ssRNA viruses; ssRNA negative-strand viruses; Orthomyxoviridae; Influenzavirus A
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Genomic context

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Location:
segment: 3
Sequence:
NC_002022.1 (25..2175)

NC_002022.1Genomic Context describing neighboring genes Neighboring gene PA-X protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002022.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Host adaptive mutations in the 2009 H1N1 pandemic influenza A virus PA gene regulate translation efficiency of viral mRNAs via GRSF1. Lutz M, et al. Commun Biol, 2022 Oct 17. PMID 36253464, Free PMC Article
  2. Structural insights into the substrate specificity of the endonuclease activity of the influenza virus cap-snatching mechanism. Kumar G, et al. Nucleic Acids Res, 2021 Feb 22. PMID 33469660, Free PMC Article
  3. Priming and realignment by the influenza a virus RdRp is dependent on the length of the host primers and the extent of base pairing to viral RNA. De Vlugt C, et al. Virology, 2019 Oct. PMID 31404845
  4. Identification of novel amino acid residues of influenza virus PA-X that are important for PA-X shutoff activity by using yeast. Oishi K, et al. Virology, 2018 Mar. PMID 29331676, Free PMC Article
  5. Computational analysis of the effect of polymerase acidic (PA) gene mutation F35L in the 2009 pandemic influenza A (H1N1) virus on binding aspects of mononucleotides in the endonuclease domain. Bhoye D, et al. Arch Virol, 2018 Apr. PMID 29273880

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Host adaptive mutations in the 2009 H1N1 pandemic influenza A virus PA gene regulate translation efficiency of viral mRNAs via GRSF1.
    Title: Host adaptive mutations in the 2009 H1N1 pandemic influenza A virus PA gene regulate translation efficiency of viral mRNAs via GRSF1.
  2. Eukaryotic Translation Elongation Factor 1 Delta Inhibits the Nuclear Import of the Nucleoprotein and PA-PB1 Heterodimer of Influenza A Virus.
    Title: Eukaryotic Translation Elongation Factor 1 Delta Inhibits the Nuclear Import of the Nucleoprotein and PA-PB1 Heterodimer of Influenza A Virus.
  3. Structural insights into the substrate specificity of the endonuclease activity of the influenza virus cap-snatching mechanism.
    Title: Structural insights into the substrate specificity of the endonuclease activity of the influenza virus cap-snatching mechanism.
  4. Priming and realignment by the influenza a virus RNA-Dependent RNA Polymerase is dependent on the length of the host primers and the extent of base pairing to viral RNA.
    Title: Priming and realignment by the influenza a virus RdRp is dependent on the length of the host primers and the extent of base pairing to viral RNA.
  5. substitutions in HA (Asp225Gly or Gln226Arg) and compensatory mutation decreasing the charge of HA (Lys123Asn, Lys157Asn, Gly158Glu, Asn159Asp, or Lys212Met) altered viral receptor-binding specificity and restored the functional balance between HA and NA; (2) Phe35Leu substitution in the PA protein increased viral polymerase activity.
    Title: [Mutations in Hemagglutinin and Polymerase Alter the Virulence of Pandemic A(H1N1) Influenza Virus].
  6. A recombinant pandemic H1N1 virus containing PA, PA-X, and NS1 genes from currently circulating viruses is fitter in replication in cultured cells and in mice and is slightly more pathogenic than the original ancestor pandemic H1N1 virus.
    Title: Functional Evolution of the 2009 Pandemic H1N1 Influenza Virus NS1 and PA in Humans.
  7. The 22 amino acids of the N-terminal of PA are important for the shutoff activity.
    Title: Identification of novel amino acid residues of influenza virus PA-X that are important for PA-X shutoff activity by using yeast.
  8. Computational analysis of the effect of polymerase acidic gene mutation F35L in the 2009 pandemic influenza A (H1N1) virus on binding aspects of mononucleotides in the endonuclease domain has been presented.
    Title: Computational analysis of the effect of polymerase acidic (PA) gene mutation F35L in the 2009 pandemic influenza A (H1N1) virus on binding aspects of mononucleotides in the endonuclease domain.
  9. The human (H1N1) and avian (H7N9) strain PA-C-terminal domain proteins exhibit the same global topology as other strains in the absence of PB1, but differ extensively in the PB1 binding pocket.
    Title: Structural analysis of H1N1 and H7N9 influenza A virus PA in the absence of PB1.
  10. The ts-mutations in PB1, PB2, and PA genes are mostly involved in the modulation of the humoral immunity, but also have a moderate effect on the cellular adaptive immune response.
    Title: [Effect of Point Mutations in the Polymerase Genes of the Influenza A/PR/8/34 (H1N1) Virus on the Immune Response in a Mouse Model].
Submit: New GeneRIF Correction See all GeneRIFs (17)

Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
polymerase PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002022.1 Reference assembly

    Range
    25..2175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_040986.1 polymerase PA [Influenza A virus (A/Puerto Rico/8/1934(H1N1))]

    See identical proteins and their annotated locations for NP_040986.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4GXH3, P03433, Q20N31, Q8JUU6
    UniProtKB/TrEMBL
    A0A1D8EMV6, A0A1U9W4S2, A0A5J6BSB7, B4UPB3, C3PQG3, C7S1X8, C7S277, F0TTJ6, F0TTS3, F0TU44, F0TU66, I6S596, I6S6F2, I6S731, I6SHZ7, I6SIR4, I6T2F0, I6T4X9, I6TBS4, I6THD6, J7GS12, R9WMJ0, S5FTI8, S5G005
    Conserved Domains (1) summary
    pfam00603
    Location:21 → 715
    Flu_PA; Influenza RNA-dependent RNA polymerase subunit PA
Nucleotide Protein
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Gene LinkOut

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