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RNF14 ring finger protein 14 [ Homo sapiens (human) ]

Gene ID: 9604, updated on 13-Apr-2024

Summary

Official Symbol
RNF14provided by HGNC
Official Full Name
ring finger protein 14provided by HGNC
Primary source
HGNC:HGNC:10058
See related
Ensembl:ENSG00000013561 MIM:605675; AllianceGenome:HGNC:10058
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARA54; HFB30; TRIAD2; HRIHFB2038
Summary
The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]
Expression
Ubiquitous expression in testis (RPKM 10.0), thyroid (RPKM 8.1) and 25 other tissues See more
Orthologs
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Genomic context

Location:
5q31.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (141949337..141990292)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (142475299..142516212)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (141346408..141369857)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene glycine cleavage system protein H (aminomethyl carrier) pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:141293283-141293820 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:141303317-141303830 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:141308886-141309386 Neighboring gene DAP3 binding cell death enhancer 1 Neighboring gene protocadherin 12 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:141336627-141337533 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:141337534-141338439 Neighboring gene uncharacterized LOC124901095 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16464 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23314 Neighboring gene glucosamine-6-phosphate deaminase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16465 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16466 Neighboring gene CRISPRi-validated cis-regulatory element chr5.3497 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23315 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16467 Neighboring gene Sharpr-MPRA regulatory region 4900 Neighboring gene mitochondrial ribosomal protein L11 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ26004

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables nuclear androgen receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity TAS
Traceable Author Statement
more info
PubMed 
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin-like protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
is_active_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF14
Names
androgen receptor associated protein 54
NP_001188294.1
NP_004281.1
NP_899645.1
NP_899646.1
NP_899647.1
NP_899648.1
XP_011536016.1
XP_016865563.1
XP_016865564.1
XP_024302033.1
XP_047273854.1
XP_047273855.1
XP_047273856.1
XP_047273857.1
XP_047273858.1
XP_047273859.1
XP_047273860.1
XP_047273861.1
XP_047273862.1
XP_047273863.1
XP_047273864.1
XP_047273865.1
XP_047273866.1
XP_054209813.1
XP_054209814.1
XP_054209815.1
XP_054209816.1
XP_054209817.1
XP_054209818.1
XP_054209819.1
XP_054209820.1
XP_054209821.1
XP_054209822.1
XP_054209823.1
XP_054209824.1
XP_054209825.1
XP_054209826.1
XP_054209827.1
XP_054209828.1
XP_054209829.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001201365.2NP_001188294.1  E3 ubiquitin-protein ligase RNF14 isoform 1

    See identical proteins and their annotated locations for NP_001188294.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Both variants encode the same isoform (1).
    Source sequence(s)
    AC005740, BC126185, BE042895, DC396586
    Consensus CDS
    CCDS4270.1
    UniProtKB/Swiss-Prot
    A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
    UniProtKB/TrEMBL
    B3KN55
    Related
    ENSP00000378027.1, ENST00000394519.5
    Conserved Domains (4) summary
    smart00647
    Location:289350
    IBR; In Between Ring fingers
    pfam01485
    Location:377433
    IBR; IBR domain, a half RING-finger domain
    pfam05773
    Location:7133
    RWD; RWD domain
    cd16628
    Location:218271
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
  2. NM_004290.5NP_004281.1  E3 ubiquitin-protein ligase RNF14 isoform 1

    See identical proteins and their annotated locations for NP_004281.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC005740, AF060544, BE042895, DC402536
    Consensus CDS
    CCDS4270.1
    UniProtKB/Swiss-Prot
    A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
    UniProtKB/TrEMBL
    B3KN55
    Related
    ENSP00000378028.2, ENST00000394520.7
    Conserved Domains (4) summary
    smart00647
    Location:289350
    IBR; In Between Ring fingers
    pfam01485
    Location:377433
    IBR; IBR domain, a half RING-finger domain
    pfam05773
    Location:7133
    RWD; RWD domain
    cd16628
    Location:218271
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
  3. NM_183398.3NP_899645.1  E3 ubiquitin-protein ligase RNF14 isoform 2

    See identical proteins and their annotated locations for NP_899645.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon compared to variant 1. The translation begins at a downstream start codon and results in an isoform (2) that has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AC005740, AF060544, BE042895, DB456366, DC402536
    Consensus CDS
    CCDS4271.1
    UniProtKB/Swiss-Prot
    Q9UBS8
    Related
    ENSP00000378022.2, ENST00000394514.6
    Conserved Domains (3) summary
    smart00647
    Location:163224
    IBR; In Between Ring fingers
    cd16628
    Location:92145
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
    pfam01485
    Location:251307
    IBR; IBR domain, a half RING-finger domain
  4. NM_183399.3NP_899646.1  E3 ubiquitin-protein ligase RNF14 isoform 1

    See identical proteins and their annotated locations for NP_899646.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants encode the same isoform (1).
    Source sequence(s)
    AC005740, AF060544, BE042895, DC396586
    Consensus CDS
    CCDS4270.1
    UniProtKB/Swiss-Prot
    A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
    UniProtKB/TrEMBL
    B3KN55
    Related
    ENSP00000348462.1, ENST00000356143.5
    Conserved Domains (4) summary
    smart00647
    Location:289350
    IBR; In Between Ring fingers
    pfam01485
    Location:377433
    IBR; IBR domain, a half RING-finger domain
    pfam05773
    Location:7133
    RWD; RWD domain
    cd16628
    Location:218271
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
  5. NM_183400.3NP_899647.1  E3 ubiquitin-protein ligase RNF14 isoform 1

    See identical proteins and their annotated locations for NP_899647.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks a segment within the 5' UTR compared to variant 1. Both variants encode the same isoform (1).
    Source sequence(s)
    AC005740, AF060544, BE042895, DC402536
    Consensus CDS
    CCDS4270.1
    UniProtKB/Swiss-Prot
    A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
    UniProtKB/TrEMBL
    B3KN55
    Related
    ENSP00000324956.3, ENST00000347642.7
    Conserved Domains (4) summary
    smart00647
    Location:289350
    IBR; In Between Ring fingers
    pfam01485
    Location:377433
    IBR; IBR domain, a half RING-finger domain
    pfam05773
    Location:7133
    RWD; RWD domain
    cd16628
    Location:218271
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
  6. NM_183401.3NP_899648.1  E3 ubiquitin-protein ligase RNF14 isoform 1

    See identical proteins and their annotated locations for NP_899648.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Both variants encode the same isoform (1).
    Source sequence(s)
    AC005740, AF060544, BE042895, DC358984
    Consensus CDS
    CCDS4270.1
    UniProtKB/Swiss-Prot
    A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
    UniProtKB/TrEMBL
    B3KN55
    Conserved Domains (4) summary
    smart00647
    Location:289350
    IBR; In Between Ring fingers
    pfam01485
    Location:377433
    IBR; IBR domain, a half RING-finger domain
    pfam05773
    Location:7133
    RWD; RWD domain
    cd16628
    Location:218271
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    141949337..141990292
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417908.1XP_047273864.1  E3 ubiquitin-protein ligase RNF14 isoform X2

    UniProtKB/TrEMBL
    B7Z229
  2. XM_047417904.1XP_047273860.1  E3 ubiquitin-protein ligase RNF14 isoform X1

    UniProtKB/Swiss-Prot
    A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
  3. XM_047417903.1XP_047273859.1  E3 ubiquitin-protein ligase RNF14 isoform X1

    UniProtKB/Swiss-Prot
    A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
  4. XM_047417899.1XP_047273855.1  E3 ubiquitin-protein ligase RNF14 isoform X1

    UniProtKB/Swiss-Prot
    A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
  5. XM_047417907.1XP_047273863.1  E3 ubiquitin-protein ligase RNF14 isoform X2

    UniProtKB/TrEMBL
    B7Z229
  6. XM_047417898.1XP_047273854.1  E3 ubiquitin-protein ligase RNF14 isoform X1

    UniProtKB/Swiss-Prot
    A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
  7. XM_047417906.1XP_047273862.1  E3 ubiquitin-protein ligase RNF14 isoform X2

    UniProtKB/TrEMBL
    B7Z229
  8. XM_047417905.1XP_047273861.1  E3 ubiquitin-protein ligase RNF14 isoform X1

    UniProtKB/Swiss-Prot
    A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
  9. XM_047417909.1XP_047273865.1  E3 ubiquitin-protein ligase RNF14 isoform X2

    UniProtKB/TrEMBL
    B7Z229
  10. XM_024446265.2XP_024302033.1  E3 ubiquitin-protein ligase RNF14 isoform X2

    UniProtKB/TrEMBL
    B7Z229
    Conserved Domains (3) summary
    smart00647
    Location:113174
    IBR; In Between Ring fingers
    pfam01485
    Location:201257
    IBR; IBR domain, a half RING-finger domain
    cl02687
    Location:779
    RWD; RWD domain
  11. XM_047417902.1XP_047273858.1  E3 ubiquitin-protein ligase RNF14 isoform X1

    UniProtKB/Swiss-Prot
    A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
  12. XM_017010075.3XP_016865564.1  E3 ubiquitin-protein ligase RNF14 isoform X2

    UniProtKB/TrEMBL
    B7Z229
    Conserved Domains (3) summary
    smart00647
    Location:113174
    IBR; In Between Ring fingers
    pfam01485
    Location:201257
    IBR; IBR domain, a half RING-finger domain
    cl02687
    Location:779
    RWD; RWD domain
  13. XM_047417900.1XP_047273856.1  E3 ubiquitin-protein ligase RNF14 isoform X1

    UniProtKB/Swiss-Prot
    A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
  14. XM_047417901.1XP_047273857.1  E3 ubiquitin-protein ligase RNF14 isoform X1

    UniProtKB/Swiss-Prot
    A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
  15. XM_011537714.4XP_011536016.1  E3 ubiquitin-protein ligase RNF14 isoform X1

    See identical proteins and their annotated locations for XP_011536016.1

    UniProtKB/Swiss-Prot
    A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
    UniProtKB/TrEMBL
    B3KN55
    Conserved Domains (4) summary
    smart00647
    Location:289350
    IBR; In Between Ring fingers
    pfam01485
    Location:377433
    IBR; IBR domain, a half RING-finger domain
    pfam05773
    Location:7133
    RWD; RWD domain
    cd16628
    Location:218271
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
  16. XM_047417910.1XP_047273866.1  E3 ubiquitin-protein ligase RNF14 isoform X2

    UniProtKB/TrEMBL
    B7Z229
  17. XM_017010074.3XP_016865563.1  E3 ubiquitin-protein ligase RNF14 isoform X2

    UniProtKB/TrEMBL
    B7Z229
    Conserved Domains (3) summary
    smart00647
    Location:113174
    IBR; In Between Ring fingers
    pfam01485
    Location:201257
    IBR; IBR domain, a half RING-finger domain
    cl02687
    Location:779
    RWD; RWD domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    142475299..142516212
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054353851.1XP_054209826.1  E3 ubiquitin-protein ligase RNF14 isoform X2

    UniProtKB/TrEMBL
    B7Z229
  2. XM_054353843.1XP_054209818.1  E3 ubiquitin-protein ligase RNF14 isoform X1

    UniProtKB/Swiss-Prot
    A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
  3. XM_054353842.1XP_054209817.1  E3 ubiquitin-protein ligase RNF14 isoform X1

    UniProtKB/Swiss-Prot
    A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
  4. XM_054353839.1XP_054209814.1  E3 ubiquitin-protein ligase RNF14 isoform X1

    UniProtKB/Swiss-Prot
    A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
  5. XM_054353848.1XP_054209823.1  E3 ubiquitin-protein ligase RNF14 isoform X2

    UniProtKB/TrEMBL
    B7Z229
  6. XM_054353838.1XP_054209813.1  E3 ubiquitin-protein ligase RNF14 isoform X1

    UniProtKB/Swiss-Prot
    A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
  7. XM_054353847.1XP_054209822.1  E3 ubiquitin-protein ligase RNF14 isoform X2

    UniProtKB/TrEMBL
    B7Z229
  8. XM_054353844.1XP_054209819.1  E3 ubiquitin-protein ligase RNF14 isoform X1

    UniProtKB/Swiss-Prot
    A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
  9. XM_054353853.1XP_054209828.1  E3 ubiquitin-protein ligase RNF14 isoform X2

    UniProtKB/TrEMBL
    B7Z229
  10. XM_054353850.1XP_054209825.1  E3 ubiquitin-protein ligase RNF14 isoform X2

    UniProtKB/TrEMBL
    B7Z229
  11. XM_054353841.1XP_054209816.1  E3 ubiquitin-protein ligase RNF14 isoform X1

    UniProtKB/Swiss-Prot
    A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
  12. XM_054353852.1XP_054209827.1  E3 ubiquitin-protein ligase RNF14 isoform X2

    UniProtKB/TrEMBL
    B7Z229
  13. XM_054353845.1XP_054209820.1  E3 ubiquitin-protein ligase RNF14 isoform X1

    UniProtKB/Swiss-Prot
    A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
  14. XM_054353854.1XP_054209829.1  E3 ubiquitin-protein ligase RNF14 isoform X2

    UniProtKB/TrEMBL
    B7Z229
  15. XM_054353840.1XP_054209815.1  E3 ubiquitin-protein ligase RNF14 isoform X1

    UniProtKB/Swiss-Prot
    A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
  16. XM_054353846.1XP_054209821.1  E3 ubiquitin-protein ligase RNF14 isoform X1

    UniProtKB/Swiss-Prot
    A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
  17. XM_054353849.1XP_054209824.1  E3 ubiquitin-protein ligase RNF14 isoform X2

    UniProtKB/TrEMBL
    B7Z229