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LOC112577536 Sharpr-MPRA regulatory region 10274 [ Homo sapiens (human) ]

Gene ID: 112577536, updated on 10-Dec-2024

Summary

Gene symbol
LOC112577536
Gene description
Sharpr-MPRA regulatory region 10274
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional enhancer by the Sharpr-MPRA technique (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in HepG2 liver carcinoma cells (group: HepG2 Activating DNase matched - State 5:Enh, candidate strong enhancer, open chromatin), with weak activity in K562 erythroleukemia cells (group: K562 Activating non-DNase unmatched - State 6:EnhF, candidate strong enhancer, flanking open chromatin). [provided by RefSeq, Jun 2021]
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Genomic context

See LOC112577536 in Genome Data Viewer
Location:
1q
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (211616567..211616861)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (210862658..210862952)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (211789909..211790203)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1788 Neighboring gene H3K27ac hESC enhancers GRCh37_chr1:211751675-211752176 and GRCh37_chr1:211752177-211752676 Neighboring gene solute carrier family 30 member 1 Neighboring gene uncharacterized LOC105372903 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:211794336-211794836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:211805695-211806270 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:211815933-211816768 Neighboring gene Sharpr-MPRA regulatory region 10021 Neighboring gene non-coding transcript regulating alternative splicing Neighboring gene farnesyl diphosphate synthase pseudogene 8 Neighboring gene NIMA related kinase 2

Genomic regions, transcripts, and products

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_060456.1 

    Range
    101..395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    211616567..211616861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    210862658..210862952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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