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Mettl5 methyltransferase 5, N6-adenosine [ Rattus norvegicus (Norway rat) ]

Gene ID: 502632, updated on 4-Jan-2025

Summary

Official Symbol
Mettl5provided by RGD
Official Full Name
methyltransferase 5, N6-adenosineprovided by RGD
Primary source
RGD:1566062
See related
EnsemblRapid:ENSRNOG00000008469 AllianceGenome:RGD:1566062
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1566062
Summary
Predicted to enable S-adenosyl-L-methionine binding activity and rRNA (adenine-N6-)-methyltransferase activity. Predicted to be involved in positive regulation of translation; rRNA methylation; and stem cell differentiation. Predicted to be located in several cellular components, including fibrillar center; postsynapse; and presynapse. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 72. Orthologous to human METTL5 (methyltransferase 5, N6-adenosine). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 205.1), Heart (RPKM 202.4) and 9 other tissues See more
Orthologs
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Genomic context

See Mettl5 in Genome Data Viewer
Location:
3q21
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (75033605..75046359, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (54625790..54638066, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (56101597..56113823, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene kelch-like family member 23 Neighboring gene small RNA binding exonuclease protection factor La Neighboring gene ubiquitin protein ligase E3 component n-recognin 3 Neighboring gene heterogeneous nuclear ribonucleoprotein C, pseudogene 5 Neighboring gene uncharacterized LOC134486377 Neighboring gene myosin IIIB

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Clone Names

  • MGC187943

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in positive regulation of translation  
involved_in rRNA methylation  
involved_in rRNA processing  
involved_in stem cell differentiation  
Component Evidence Code Pubs
located_in cytosol  
located_in cytosol  
located_in fibrillar center  
located_in fibrillar center  
located_in nucleolus  
located_in nucleus  
located_in postsynapse  
located_in presynapse  

General protein information

Preferred Names
rRNA N6-adenosine-methyltransferase METTL5
Names
methyltransferase like 5
methyltransferase-like protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114181.1NP_001107653.1  rRNA N6-adenosine-methyltransferase METTL5

    See identical proteins and their annotated locations for NP_001107653.1

    Status: VALIDATED

    Source sequence(s)
    BC158754, CH473949
    UniProtKB/TrEMBL
    A6HM25, B0BNB3, F7FIR4
    Related
    ENSRNOP00000011304.5, ENSRNOT00000011303.7
    Conserved Domains (1) summary
    COG2263
    Location:7209
    COG2263; Predicted RNA methylase [General function prediction only]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    75033605..75046359 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284401.1XP_063140471.1  rRNA N6-adenosine-methyltransferase METTL5 isoform X2

    UniProtKB/TrEMBL
    A6HM25, B0BNB3, F7FIR4
  2. XM_063284400.1XP_063140470.1  rRNA N6-adenosine-methyltransferase METTL5 isoform X1

  3. XM_039105726.2XP_038961654.1  rRNA N6-adenosine-methyltransferase METTL5 isoform X3

    Conserved Domains (1) summary
    COG2263
    Location:7171
    COG2263; Predicted RNA methylase [General function prediction only]
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