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Mettl8 methyltransferase 8, tRNA N3-cytidine [ Rattus norvegicus (Norway rat) ]

Gene ID: 502633, updated on 4-Jan-2025

Summary

Official Symbol
Mettl8provided by RGD
Official Full Name
methyltransferase 8, tRNA N3-cytidineprovided by RGD
Primary source
RGD:1561059
See related
EnsemblRapid:ENSRNOG00000009382 AllianceGenome:RGD:1561059
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561059; AABR07052486.1
Summary
Predicted to enable histone acetyltransferase activity; mRNA methyltransferase activity; and tRNA (cytidine-3-)-methyltransferase activity. Predicted to be involved in RNA metabolic process and positive regulation of mitochondrial translation. Predicted to act upstream of or within fat cell differentiation and skeletal muscle tissue development. Predicted to be located in cytoplasm and nucleus. Predicted to be active in mitochondrial matrix. Orthologous to human METTL8 (methyltransferase 8, tRNA N3-cytidine). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 39.2), Lung (RPKM 22.4) and 9 other tissues See more
Orthologs
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Genomic context

See Mettl8 in Genome Data Viewer
Location:
3q22
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (76140465..76271367, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (55731453..55863652, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (57257394..57642096, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486287 Neighboring gene ribosomal protein L15 like 2 Neighboring gene uncharacterized LOC134486104 Neighboring gene uncharacterized LOC134486103 Neighboring gene DDB1 and CUL4 associated factor 17 Neighboring gene cytochrome b reductase 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Component Evidence Code Pubs
NOT is_active_in cytoplasm  
located_in cytoplasm  
is_active_in mitochondrial matrix  
is_active_in mitochondrion  
located_in mitochondrion PubMed 
NOT is_active_in nucleus  
located_in nucleus  

General protein information

Preferred Names
tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial
Names
mRNA N(3)-methylcytidine methyltransferase METTL8
methyltransferase 8, methylcytidine
methyltransferase like 8
methyltransferase-like protein 8
NP_001386442.1
NP_001386443.1
XP_008760176.1
XP_038962292.1
XP_038962293.1
XP_063140473.1
XP_063140474.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399513.1NP_001386442.1  tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HM36, A6HM37
    Related
    ENSRNOP00000067958.3, ENSRNOT00000075860.3
    Conserved Domains (1) summary
    pfam13649
    Location:190293
    Methyltransf_25; Methyltransferase domain
  2. NM_001399514.1NP_001386443.1  tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    76140465..76271367 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284403.1XP_063140473.1  tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform X4

  2. XM_039106364.2XP_038962292.1  tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform X2

    Related
    ENSRNOP00000098991.1, ENSRNOT00000139862.1
    Conserved Domains (1) summary
    pfam13649
    Location:202305
    Methyltransf_25; Methyltransferase domain
  3. XM_008761954.4XP_008760176.1  tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_008760176.1

    UniProtKB/TrEMBL
    A6HM36, D3ZFN6
    Related
    ENSRNOP00000055322.5, ENSRNOT00000058524.7
    Conserved Domains (2) summary
    COG0500
    Location:197392
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    pfam08242
    Location:203307
    Methyltransf_12; Methyltransferase domain
  4. XM_039106365.2XP_038962293.1  tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform X3

    UniProtKB/TrEMBL
    A6HM36
    Related
    ENSRNOP00000105307.1, ENSRNOT00000138988.1
    Conserved Domains (1) summary
    pfam13649
    Location:165268
    Methyltransf_25; Methyltransferase domain
  5. XM_063284404.1XP_063140474.1  tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform X5

    UniProtKB/TrEMBL
    A0A096MK97
    Related
    ENSRNOP00000111422.1, ENSRNOT00000134483.1

RNA

  1. XR_005502190.2 RNA Sequence

  2. XR_005502191.2 RNA Sequence

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