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Selenoh selenoprotein H [ Rattus norvegicus (Norway rat) ]

Gene ID: 502642, updated on 4-Jan-2025

Summary

Official Symbol
Selenohprovided by RGD
Official Full Name
selenoprotein Hprovided by RGD
Primary source
RGD:1563348
See related
EnsemblRapid:ENSRNOG00000054563 AllianceGenome:RGD:1563348
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Selh; RGD1563348
Summary
This gene encodes a nucleolar protein, which belongs to the SelWTH family. It functions as an oxidoreductase, and has been shown to protect neurons against UVB-induced damage by inhibiting apoptotic cell death pathways, promote mitochondrial biogenesis and mitochondrial function, and suppress cellular senescence through genome maintenance and redox regulation. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2016]
Expression
Biased expression in Thymus (RPKM 276.4), Kidney (RPKM 274.4) and 9 other tissues See more
Orthologs
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Genomic context

See Selenoh in Genome Data Viewer
Location:
3q24
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (90158541..90160108, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (69751850..69753417, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (72070342..72071909, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene catenin delta 1 Neighboring gene BTB domain containing 18 Neighboring gene thioredoxin-related transmembrane protein 2 Neighboring gene mediator complex subunit 19 Neighboring gene zinc finger DHHC-type palmitoyltransferase 5 Neighboring gene uncharacterized LOC120101590

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114939.2NP_001108411.1  selenoprotein H

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BQ781777, FQ144408
    Related
    ENSRNOP00000074642.3, ENSRNOT00000082857.3
    Conserved Domains (1) summary
    cl01407
    Location:30113
    Rdx; Rdx family
  2. NM_001321292.1NP_001308221.1  selenoprotein H

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate donor splice site at the penultimate exon in the 3' non-coding region compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BQ204240, BQ781777, FQ144408
    Conserved Domains (1) summary
    cl01407
    Location:30113
    Rdx; Rdx family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    90158541..90160108 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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