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LDHAL6B lactate dehydrogenase A like 6B [ Homo sapiens (human) ]

Gene ID: 92483, updated on 4-Jan-2025

Summary

Official Symbol
LDHAL6Bprovided by HGNC
Official Full Name
lactate dehydrogenase A like 6Bprovided by HGNC
Primary source
HGNC:HGNC:21481
See related
Ensembl:ENSG00000171989 AllianceGenome:HGNC:21481
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LDHL; LDH6B; LDHAL6
Summary
Predicted to enable L-lactate dehydrogenase activity. Involved in lactate metabolic process and pyruvate metabolic process. Located in nucleus. Part of cytoplasm. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See LDHAL6B in Genome Data Viewer
Location:
15q22.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (59206843..59208588)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (57008917..57010662)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (59499042..59500787)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:59423635-59424134 Neighboring gene cyclin B2 Neighboring gene Sharpr-MPRA regulatory region 4265 Neighboring gene myosin IE Neighboring gene OCT4 hESC enhancer GRCh37_chr15:59453332-59453833 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9486 Neighboring gene microRNA 2116 Neighboring gene RNA, U4 small nuclear 80, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:59521359-59521858 Neighboring gene Sharpr-MPRA regulatory region 2447 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6487 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:59596416-59596592 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9487 Neighboring gene NANOG hESC enhancer GRCh37_chr15:59620781-59621282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9488 Neighboring gene RNA, U6 small nuclear 212, pseudogene

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables L-lactate dehydrogenase activity  
enables L-lactate dehydrogenase activity  
enables protein binding PubMed 
Process Evidence Code Pubs
involved_in lactate metabolic process  
involved_in lactate metabolic process PubMed 
involved_in pyruvate metabolic process  
involved_in pyruvate metabolic process PubMed 
involved_in pyruvate metabolic process  
Component Evidence Code Pubs
located_in cytoplasm PubMed 
located_in mitochondrial matrix  
is_active_in mitochondrion  
located_in nucleus PubMed 
part_of oxidoreductase complex PubMed 

General protein information

Preferred Names
L-lactate dehydrogenase A-like 6B
Names
lactate dehydrogenase A-like 6
testicular tissue protein Li 105
NP_149972.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033195.3NP_149972.1  L-lactate dehydrogenase A-like 6B

    See identical proteins and their annotated locations for NP_149972.1

    Status: VALIDATED

    Source sequence(s)
    AY642121, DB511998
    Consensus CDS
    CCDS10171.1
    UniProtKB/Swiss-Prot
    Q6DUY4, Q96LI2, Q9BYZ2
    UniProtKB/TrEMBL
    A0A140VJM9
    Related
    ENSP00000302393.4, ENST00000307144.6
    Conserved Domains (2) summary
    cd05293
    Location:68376
    LDH_1; A subgroup of L-lactate dehydrogenases
    TIGR01771
    Location:74374
    L-LDH-NAD; L-lactate dehydrogenase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    59206843..59208588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    57008917..57010662
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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