Apoptosis
A form of programmed cell death that begins when a cell receives internal or external signals, then proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopods, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing, and ends with the death of the cell.
Exact Synonyms
Apoptosis
APOPTOSIS
apoptosis
Apoptotic Process
PCD
Programmed Cell Death
programmed cell death
class Information
ALT_DEFINITION
- A form of programmed cell death triggered by internal or external signals that results in a series of characteristic morphological changes.
- A type of cell death in which a series of molecular steps in a cell leads to its death. This is the body's normal way of getting rid of unneeded or abnormal cells. The process of programmed cell death may be blocked in cancer cells.
code
C17557
Contributing_Source
CDISC
DesignNote
Important in ontogenesis, tumorigenesis, tissue turnover, lymphocyte selection and function and hormone-induced atrophy.
in_subset
Legacy Concept Name
Apoptosis
Preferred_Name
Apoptosis
Semantic_Type
Phenomenon or Process
UMLS_CUI
C0162638
class Relations
Subclass of
Related from
Gene_Plays_Role_In_Process
- ITGAM Gene
- AGTR2 Gene
- TNFRSF12A Gene
- IL3 Gene
- BBC3 Gene
- PDCD4 Gene
- CDK11A Gene
- CCR8 Gene
- TFAP4 Gene
- KLLN Gene
- CCN1 Gene
- C19orf12 Gene
- GADD45A Gene
- MX1 Gene
- TNFRSF11B Gene
- PIK3R2 Gene
- MAP2K6 Gene
- GADD45B Gene
- PNMA2 Gene
- KHDRBS1 Gene
- YARS1 Gene
- CASP5 Gene
- PNMA1 Gene
- PTMA Gene
- RIPK3 Gene
- TRAF1 Gene
- NOD2 Gene
- TNFRSF18 Gene
- SCRIB Gene
- RIPK1 Gene
- FADD Gene
- WWOX Gene
- TNFSF12 Gene
- ABL1 Gene
- ACHE Gene
- BECN1 Gene
- CD14 Gene
- DAXX Gene
- EIF5A Gene
- TNFRSF21 Gene
- TNFSF10 Gene
- DCC Gene
- BRAF Gene
- NOTCH1 Gene
- TNF Gene
- NFKB1 Gene
- UBE4B Gene
- MELK Gene
- TFDP1 Gene
- TNFRSF19 Gene
- ACVR1C Gene
- RAD21 Gene
- RIPK2 Gene
- TGM2 Gene
- DEPTOR Gene
- LGALS7B Gene
- ZNF385B Gene
- CASP10 Gene
- PAX3 Gene
- LGALS8 Gene
- E2F1 Gene
- STK3 Gene
- MAP3K7 Gene
- IL1B Gene
- PERP Gene
- PSME3 Gene
- CASP8 Gene
- CIB1 Gene
- CASP1 Gene
- BCL-2 Gene Family
- TNFRSF1B Gene
- CXCR4 Gene
- NAE1 Gene
- MAPK14 Gene
- AATF Gene
- PHLDA2 Gene
- BUB1B Gene
- CASP3 Gene
- IRF1 Gene
- SFRP1 Gene
- NBN Gene
- TNFAIP3 Gene
- TP53BP2 Gene
- CARD8 Gene
- FOXL2 Gene
- MAGED1 Gene
- ANGPT1 Gene
- ING1 Gene
- PRF1 Gene
- PMAIP1 Gene
- STAT5B Gene
- SQSTM1 Gene
- FASTK Gene
- ADRA1A Gene
- DOCK1 Gene
- PREX1 Gene
- Apoptosis Regulation Gene
- VDAC1 Gene
- ATM Gene
- PSMD10 Gene
- PSEN2 Gene
- DUSP22 Gene
- PSENEN Gene
- PAK6 Gene
- IFNA2 Gene
- TFDP2 Gene
- CASP2 Gene
- TNFRSF25 Gene
- CASP9 Gene
- TPD52L1 Gene
- PGAP2 Gene
- PSMB5 Gene
- PTPN6 Gene
- TNF Receptor Family Gene
- CALR Gene
- APP Gene
- BCL6 Gene
- NRP1 Gene
- PPP1R13L Gene
- PAK1 Gene
- CASP6 Gene
- TAF6 Gene
- HUWE1 Gene
- PPP2R1A Gene
- CDK11B Gene
- CD27 Gene
- SATB2 Gene
- GDNF Gene
- TRAF2 Gene
- CAV2 Gene
- MAPK9 Gene
- IAPP Gene
- LGALS7 Gene
- BEX3 Gene
- TNFRSF10A Gene
- MAPK8 Gene
- YWHAZ Gene
- PDCD1 Gene
- BECN2 Gene
- TNFSF9 Gene
- PRKCE Gene
- TNFSF11 Gene
- Caspase Gene
- DNM1L Gene
- PTK2 Gene
- SNCA Gene
- CASP4 Gene
- NFKBIA Gene
- CASP7 Gene
- PTK2B Gene
- TNFSF14 Gene
- TNFRSF1A Gene
- RELT Gene
- FASLG Gene
- TP53AIP1 Gene
- STK4 Gene
- RAC1 Gene
- GAS2 Gene
- FAS Gene
- UBA3 Gene
- STK11 Gene
- KRT20 Gene
- SIAH2 Gene
- FOXO3 Gene
Chemical_Or_Drug_Has_Physiologic_Effect
- Fenretinide Lipid Matrix
- LMB-9 Immunotoxin
- Belotecan Hydrochloride
- Cabazitaxel
- Oral Irinotecan Hydrochloride Formulation VAL-413
- Fenretinide Phospholipid Suspension ST-001
- Alitretinoin
- Gimatecan
- Liposomal Oxaliplatin
- Shark Cartilage Extract AE-941
- Fenretinide
- DACH Polymer Platinate AP5346
- Irinotecan
- Irinotecan Hydrochloride
- LMB-7 Immunotoxin
- Oxaliplatin
- LMB-1 Immunotoxin
- Pegylated Liposomal Irinotecan
Gene_Product_Plays_Role_In_Biological_Process
- Pleckstrin Homology-Like Domain Family A Member 2
- Eukaryotic Translation Initiation Factor 5A-1
- Paraneoplastic Antigen Ma2
- Protein JTB
- Killin
- Nuclear Factor NF-kappa-B p50 Subunit
- BCL-2 Family Protein
- Transcription Factor AP-4
- Tumor Protein D53
- Caspase
- Apoptosis Regulator
- E3 Ubiquitin-Protein Ligase SIAH2
- Cleft Lip and Palate Transmembrane Protein 1-Like Protein
- WW Domain-Containing Oxidoreductase
Biological_Process_Has_Result_Biological_Process