A fusion gene that results from a translocation t(9;22)(q34;q11) that fuses the 5' part of the BCR gene to the 5' side of exon 2 of the ABL1 gene. There are 3 potential products that are formed depending on which BCR exon has the breakpoint. All of the protein products have constitutively active tyrosine kinase activity. This fusion is associated with both chronic myeloid leukemia and acute lymphoblastic leukemia.
class Information
A gene formed when pieces of chromosomes 9 and 22 break off and trade places. The ABL gene from chromosome 9 joins to the BCR gene on chromosome 22, to form the BCR-ABL fusion gene. The changed chromosome 22 with the fusion gene on it is called the Philadelphia chromosome. The BCR-ABL fusion gene is found in most patients with chronic myelogenous leukemia (CML), and in some patients with acute lymphoblastic leukemia (ALL) or acute myelogenous leukemia (AML).
C94600
- CPTAC
- CTRP
BCR/ABL1 Fusion Gene
BCR/ABL1 Fusion Gene
Gene or Genome
C1835417
class Relations
- Fusion Gene
- Gene_Has_Abnormalitysomet(9;22)(q34.1;q11.2)
- Gene_Involved_In_Pathogenesis_Of_DiseasesomeAcute Myeloid Leukemia with BCR-ABL1
- Gene_Involved_In_Pathogenesis_Of_DiseasesomeChronic Myeloid Leukemia, BCR-ABL1 Positive
- Gene_Involved_In_Pathogenesis_Of_DiseasesomeB Lymphoblastic Leukemia/Lymphoma with t(9;22)(q34.1;q11.2); BCR-ABL1
- Gene_Involved_In_Pathogenesis_Of_DiseasesomeMixed Phenotype Acute Leukemia with BCR-ABL1 Fusion
- Gene_Plays_Role_In_ProcesssomeSignal Transduction
- Gene_Plays_Role_In_ProcesssomeTyrosine Phosphorylation