Abstract
An asphyxiated neonate with pyridoxine-dependent seizures and associated transient nonketotic hyperglycinemia is reported. Frequent seizures and their resultant hypoxic-ischemic insult may have led to the elevation of the cerebrospinal fluid glycine level in this patient. Early diagnosis and treatment of pyridoxine-dependent seizures is essential for an improved neurologic outcome.
MeSH terms
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Asphyxia Neonatorum / complications*
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Asphyxia Neonatorum / metabolism
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Brain / metabolism
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Electroencephalography
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Glycine / metabolism
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Humans
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Hyperglycinemia, Nonketotic / etiology*
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Hyperglycinemia, Nonketotic / metabolism*
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Infant, Newborn
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Male
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Pyridoxal Phosphate / therapeutic use
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Seizures / etiology*
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Seizures / physiopathology
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Treatment Outcome
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Vitamin B 6 Deficiency / complications*
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Vitamin B 6 Deficiency / drug therapy
Substances
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Pyridoxal Phosphate
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Glycine