Abstract
The gene (ybeN) coding for nicotinate mononucleotide adenylyltransferase, an NAD(P) biosynthetic enzyme, has been identified and overexpressed in Escherichia coli. This enzyme catalyzes the reversible adenylation of nicotinate mononucleotide and shows product inhibition. The rate of adenylation of nicotinate mononucleotide is at least 20 times faster than the rate of adenylation of nicotinamide mononucleotide.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Catalysis
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DNA, Bacterial / chemistry
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Escherichia coli / enzymology*
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Escherichia coli / genetics*
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Models, Chemical
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Nicotinamide Mononucleotide / analogs & derivatives
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Nicotinamide Mononucleotide / metabolism
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Nicotinamide-Nucleotide Adenylyltransferase*
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Nucleotidyltransferases / genetics*
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Terminology as Topic
Substances
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DNA, Bacterial
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Nicotinamide Mononucleotide
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nicotinate mononucleotide
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Nucleotidyltransferases
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Nicotinamide-Nucleotide Adenylyltransferase
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nicotinic acid mononucleotide adenylyltransferase