Eukaryotic transcription: the core of eukaryotic gene activation

K M Johnson; K Mitsouras; M Carey

doi:10.1016/s0960-9822(01)00306-2

Eukaryotic transcription: the core of eukaryotic gene activation

Curr Biol. 2001 Jul 10;11(13):R510-3. doi: 10.1016/s0960-9822(01)00306-2.

Authors

K M Johnson¹, K Mitsouras, M Carey

Affiliation

¹ Department of Biological Chemistry, UCLA School of Medicine, 10833 LeConte Avenue, Los Angeles, California 90095-1737, USA.

PMID: 11470422
DOI: 10.1016/s0960-9822(01)00306-2

Abstract

Gene expression is controlled by interactions between activators and coactivators. These interactions in turn are regulated by signaling pathways and by chromatin remodeling events. Recent studies indicate that the final arbiter of gene regulation is a coactivator scaffold at the promoter.

MeSH terms

Animals
Chromatin / metabolism
Eukaryotic Cells / metabolism
Macromolecular Substances
Models, Biological
Transcription Factor TFIID
Transcription Factors / physiology
Transcription Factors, TFII / physiology
Transcriptional Activation*

Substances

Chromatin
Macromolecular Substances
Transcription Factor TFIID
Transcription Factors
Transcription Factors, TFII