Abstract
The TGF-beta superfamily consists of an array of ligands including BMP, TGF-beta, activin, and nodal subfamilies. The extensive range of biological effects elicited by TGF-beta family signaling is due in part to the large numbers and promiscuity of types I and II TGF-beta family member receptors. Alk8 is a novel type I TGF-beta family member receptor first identified in zebrafish [Dev. Dyn. 211 (4) (1998) 352], which participates in BMP signaling pathways [Development 128 (6) (2001) 849; Development 128 (6) (2001) 859; Mech. Dev. 100 (2) (2001) 275; J. Dent. Res. 80 (11) (2001) 1968]. Here we report that Alk8 also forms active signaling complexes with TGF-beta in the presence of TGF-betaRII. These results expand the signaling repertoire of zAlk8 by demonstrating an ability to participate in two distinct TGF-beta subfamily signaling pathways.
MeSH terms
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Activin Receptors, Type I*
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Amino Acid Sequence
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Animals
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Blotting, Northern
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Blotting, Western
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Bone Morphogenetic Proteins / metabolism
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Cell Line
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Cross-Linking Reagents / pharmacology
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Humans
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In Situ Hybridization
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Ligands
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Luciferases / metabolism
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Mice
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Molecular Sequence Data
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Mutation
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Precipitin Tests
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Protein Binding
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Protein Serine-Threonine Kinases*
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Protein Structure, Tertiary
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Receptor, Transforming Growth Factor-beta Type II
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Receptors, Transforming Growth Factor beta / chemistry*
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Receptors, Transforming Growth Factor beta / metabolism*
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Reverse Transcriptase Polymerase Chain Reaction
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Signal Transduction
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Tissue Distribution
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Transforming Growth Factor beta / metabolism*
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Zebrafish
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Zebrafish Proteins / chemistry*
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Zebrafish Proteins / metabolism*
Substances
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Bone Morphogenetic Proteins
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Cross-Linking Reagents
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Ligands
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Receptors, Transforming Growth Factor beta
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Transforming Growth Factor beta
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Zebrafish Proteins
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Luciferases
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Protein Serine-Threonine Kinases
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Activin Receptors, Type I
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Receptor, Transforming Growth Factor-beta Type II
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acvr1l protein, zebrafish