Synaptic plasticity: importance of proteasome-mediated protein turnover

Curr Biol. 2003 Jul 1;13(13):R514-6. doi: 10.1016/s0960-9822(03)00443-3.

Abstract

The ubiquitin-proteasome system regulates protein degradation in every eukaryotic cell. Recent work has shown that protein turnover mediated by the ubiquitin-proteasome system plays a key role in synaptic plasticity.

Publication types

  • Review

MeSH terms

  • Axons / physiology
  • Cysteine Endopeptidases / metabolism*
  • Multienzyme Complexes / metabolism*
  • Proteasome Endopeptidase Complex
  • Proteins / metabolism*
  • Synapses / physiology*
  • Ubiquitin / metabolism*
  • Ubiquitin-Protein Ligases / metabolism

Substances

  • Multienzyme Complexes
  • Proteins
  • Ubiquitin
  • Ubiquitin-Protein Ligases
  • Cysteine Endopeptidases
  • Proteasome Endopeptidase Complex