Abstract
The unkempt gene of Drosophila encodes a set of embryonic RNAs, which are abundant during early stages of embryogenesis and are present ubiquitously in most somatic tissues from the syncytial embryo through stage 15 of embryogenesis. Expression of unkempt RNAs becomes restricted predominantly to the central nervous system in stages 16 and early 17. Analysis of cDNAs from this locus reveals the presence of five Cys3His fingers in the protein product. Isolation and analysis of mutations affecting the unkempt gene, including complete deletions of this gene, indicate that there is no zygotic requirement for unkempt during embryogenesis, presumably due to the contribution of maternally supplied RNA, although the gene is essential during post-embryonic development.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Central Nervous System / embryology
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Central Nervous System / metabolism
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Consensus Sequence
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DNA-Binding Proteins / biosynthesis
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DNA-Binding Proteins / genetics*
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DNA-Binding Proteins / physiology
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Drosophila Proteins*
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Drosophila melanogaster / embryology
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Drosophila melanogaster / genetics*
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Embryo, Nonmammalian / metabolism
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Gene Expression
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Genes*
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Genes, Lethal
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Molecular Sequence Data
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Morphogenesis
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Nerve Tissue Proteins / biosynthesis
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Nerve Tissue Proteins / genetics
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Nerve Tissue Proteins / physiology
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Protein Conformation
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RNA, Messenger / biosynthesis
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Zinc Fingers / genetics*
Substances
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DNA-Binding Proteins
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Drosophila Proteins
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Nerve Tissue Proteins
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RNA, Messenger
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unk protein, Drosophila
Associated data
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GENBANK/X12536
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GENBANK/X61776
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GENBANK/X61777
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GENBANK/X61778
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GENBANK/X61779
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GENBANK/X61780
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GENBANK/X61781
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GENBANK/X66930
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GENBANK/X66931
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GENBANK/Z11527