Phosphatidylinositol phosphate kinases

M L Giudici; K A Hinchliffe; R F Irvine

Phosphatidylinositol phosphate kinases

J Endocrinol Invest. 2004;27(6 Suppl):137-42.

Authors

M L Giudici¹, K A Hinchliffe, R F Irvine

Affiliation

¹ Department of Pharmacology, University of Cambridge, Cambridge, UK.

PMID: 15481814

Abstract

Phosphatidylinositol 4,5-bisphosphate is a multi-functional lipid, whose proposed functions now number more than twenty, covering many aspects of cell biology in several different subcellular compartments. The enzymes primarily responsible for synthesizing this lipid, the Type I phosphatidylinositol 4-phosphate 5-kinases, are therefore a tightly regulated and diverse family. Here we review our current knowledge about these enzymes and how they may be regulated.

Publication types

Review

MeSH terms

Amino Acid Sequence
Animals
Cloning, Molecular
GTP-Binding Proteins / metabolism
Humans
Molecular Sequence Data
Phosphatidic Acids / metabolism
Phosphatidylinositol 4,5-Diphosphate / physiology*
Phosphorylation
Phosphotransferases (Alcohol Group Acceptor) / genetics
Phosphotransferases (Alcohol Group Acceptor) / physiology*
Substrate Specificity

Substances

Phosphatidic Acids
Phosphatidylinositol 4,5-Diphosphate
Phosphotransferases (Alcohol Group Acceptor)
1-phosphatidylinositol-4-phosphate 5-kinase
GTP-Binding Proteins