Evolution of the NadR regulon in Enterobacteriaceae

J Bioinform Comput Biol. 2005 Aug;3(4):1007-19. doi: 10.1142/s0219720005001387.

Abstract

The NAD biosynthetic pathway and NAD transformations in E. coli and S. typhi are well characterized. Using comparative genomics methods we describe the NadR regulon in other Enterobacteriaceae, identity new candidate regulon members and demonstrate that even a very simple regulon covering an essential methabolic pathway could be different in closely related genomes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Proteins / genetics*
  • Chromosome Mapping / methods*
  • DNA, Bacterial / genetics*
  • Enterobacteriaceae / genetics*
  • Enterobacteriaceae / metabolism
  • Evolution, Molecular*
  • Gene Expression Regulation, Bacterial / genetics
  • Regulon / genetics*
  • Repressor Proteins / genetics*
  • Sequence Analysis, DNA / methods*
  • Species Specificity

Substances

  • Bacterial Proteins
  • DNA, Bacterial
  • NadR protein, bacteria
  • Repressor Proteins