Abstract
The self-renewal and pluripotency of embryonic stem cells (ESCs) is regulated by a network, which consists of a series of cell factors in microenviroments, a chain of transcription factors and certain signal conduction pathways. This article reviews recent progress in this field to elucidate the mechanism involved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Bone Morphogenetic Proteins / metabolism
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DNA-Binding Proteins / metabolism
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Embryonic Stem Cells / cytology*
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Fibroblast Growth Factors / metabolism
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Homeodomain Proteins / metabolism
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Humans
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Mice
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Nanog Homeobox Protein
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Octamer Transcription Factor-3 / metabolism
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Organic Cation Transport Proteins / metabolism
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Signal Transduction
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Transcription, Genetic
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Transforming Growth Factor beta / metabolism
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Wnt Proteins / metabolism
Substances
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Bone Morphogenetic Proteins
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DNA-Binding Proteins
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Homeodomain Proteins
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NANOG protein, human
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Nanog Homeobox Protein
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Nanog protein, mouse
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Octamer Transcription Factor-3
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Organic Cation Transport Proteins
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POU5F1 protein, human
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Pou5f1 protein, mouse
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Transforming Growth Factor beta
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Wnt Proteins
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solute carrier family 22 (organic cation transporter), member 3
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Fibroblast Growth Factors