Abstract
In the present work, the effects of colchicine (COL) and/or all-trans retinoic acid (ATRA) on expression of rexinoid receptors (RXRs) (alpha, beta, gamma), thyroid hormone receptor alpha and coregulators N-CoR, SMRT and SRC-1 mRNA in primary rat hepatocytes as a model of no-proliferating cells were investigated. Treatment with these components, either alone or in combination, induced differences of the expression profiles between distinct treatment groups.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cells, Cultured
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Colchicine / administration & dosage*
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Dose-Response Relationship, Drug
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Drug Interactions
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Gene Expression Regulation / drug effects
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Gene Expression Regulation / physiology
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Rats
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Receptors, Cytoplasmic and Nuclear / metabolism*
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Receptors, Retinoic Acid / metabolism*
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Receptors, Thyroid Hormone / metabolism*
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Repressor Proteins / metabolism*
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Tretinoin / administration & dosage*
Substances
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Receptors, Cytoplasmic and Nuclear
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Receptors, Retinoic Acid
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Receptors, Thyroid Hormone
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Repressor Proteins
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Tretinoin
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Colchicine