Familial dyskeratotic comedones

Indian J Dermatol Venereol Leprol. 2008 Mar-Apr;74(2):142-4. doi: 10.4103/0378-6323.39700.

Abstract

Familial dyskeratotic comedones (FDC) is a rare autosomal dominant inherited condition, characterized by widespread, symmetrically scattered, comedone-like, hyperkeratotic papules, which are cosmetically unappealing. These lesions appear around puberty and show a predilection to involve the trunk, arms and face. The lesions are asymptomatic and gradually worsen with time. Histology shows invagination of the epidermis with a lamellar keratinous plug and focal evidence of dyskeratosis. This condition is generally refractory to therapy. We report here two cases with this rare disorder who had a strong familial history of the same disorder.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Female
  • Humans
  • Keratosis / diagnosis*
  • Keratosis / genetics*
  • Keratosis / pathology
  • Male