Choroidal metastases from lung adenocarcinoma

Clin Transl Oncol. 2009 Oct;11(10):694-7. doi: 10.1007/s12094-009-0426-7.

Abstract

A 32-year-old woman presented with an unknown visual deficit. Fundus examination revealed a lesion compatible with a metastatic focus. Diagnostic workup revealed a lung mass and the biopsy was compatible with lung adenocarcinoma. The intraocular lesion was the only metastatic site at the time of diagnosis. She received local choroidal treatment and further systemic therapy. A pneumonectomy was performed. Five months later she progressed systemically and has since then received several lines of chemotherapy. Choroidal metastases are an infrequent site of systemic dissemination and associated with a poor prognosis, with a median survival of around 2 months if it is the first manifestation of a lung neoplasm. Here we review the literature on choroidal metastases, their treatment options and epidemiology.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / diagnostic imaging
  • Adenocarcinoma / secondary*
  • Adenocarcinoma / therapy
  • Adult
  • Antineoplastic Agents / therapeutic use
  • Choroid Neoplasms / diagnosis
  • Choroid Neoplasms / drug therapy
  • Choroid Neoplasms / secondary*
  • Female
  • Fluorescein Angiography
  • Humans
  • Lung Neoplasms / diagnostic imaging
  • Lung Neoplasms / pathology*
  • Lung Neoplasms / therapy
  • Pneumonectomy
  • Tomography, X-Ray Computed
  • Treatment Outcome

Substances

  • Antineoplastic Agents