COX-2 and PGE2-dependent immunomodulation in breast cancer

Prostaglandins Other Lipid Mediat. 2011 Nov;96(1-4):14-20. doi: 10.1016/j.prostaglandins.2011.08.005. Epub 2011 Aug 31.

Abstract

COX-derived prostanoids play multiple roles in inflammation and cancer. This review highlights research examining COX-2 and PGE(2)-dependent regulation of immune cell polarization and function within the tumor microenvironment, particularly as it pertains to breast cancer. Appreciating PGE(2)-mediated immunomodulation is important in understanding how tumors evade immune surveillance by re-educating infiltrating inflammatory and immune cells to support tumorigenesis. Elucidation of the multiple and complex influences exerted by tumor stromal components may lead to targeted therapies in breast and other cancers that restrain microenvironmental permissiveness and maintain natural defenses against malignancies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / therapeutic use
  • Breast Neoplasms / drug therapy
  • Breast Neoplasms / genetics
  • Breast Neoplasms / immunology*
  • Breast Neoplasms / metabolism
  • Carcinoma / drug therapy
  • Carcinoma / genetics
  • Carcinoma / immunology*
  • Carcinoma / metabolism
  • Cell Transformation, Neoplastic / drug effects
  • Cell Transformation, Neoplastic / genetics
  • Cell Transformation, Neoplastic / immunology*
  • Cell Transformation, Neoplastic / metabolism
  • Cyclooxygenase 2 / genetics
  • Cyclooxygenase 2 / immunology*
  • Cyclooxygenase 2 / metabolism
  • Cytokines / genetics
  • Cytokines / immunology
  • Cytokines / metabolism
  • Dinoprostone / genetics
  • Dinoprostone / immunology*
  • Dinoprostone / metabolism
  • Dinoprostone / pharmacology
  • Female
  • Gene Expression Regulation, Neoplastic / immunology
  • Humans
  • Immunomodulation*
  • Immunotherapy / methods*
  • Lymphocytes, Tumor-Infiltrating / drug effects
  • Lymphocytes, Tumor-Infiltrating / immunology
  • Lymphocytes, Tumor-Infiltrating / metabolism
  • Macrophages / drug effects
  • Macrophages / immunology
  • Macrophages / metabolism
  • Mice
  • Signal Transduction / genetics
  • Signal Transduction / immunology
  • T-Lymphocytes, Regulatory / drug effects
  • T-Lymphocytes, Regulatory / immunology
  • T-Lymphocytes, Regulatory / metabolism
  • Tumor Microenvironment / immunology*

Substances

  • Antineoplastic Agents
  • Cytokines
  • Cyclooxygenase 2
  • PTGS2 protein, human
  • Dinoprostone