Characterization and localization to human chromosome 1 of human fast-twitch skeletal muscle calsequestrin gene

Somat Cell Mol Genet. 1990 Mar;16(2):185-9. doi: 10.1007/BF01233048.

Abstract

A genomic clone encoding human fast-twitch skeletal muscle calsequestrin was isolated, and the amino acid sequence of the protein and the exon-intron boundaries of the gene were deduced from its sequence. A comparison with the rabbit gene showed that the sequence Glu-Asp-Asp-Asp-Asp near the COOH terminus of the rabbit sequence is lacking in the human gene. The calsequestrin gene was assigned to human chromosome 1 through the use of a human-mouse somatic cell hybrid mapping panel.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Calsequestrin / analysis
  • Calsequestrin / genetics*
  • Chromosome Mapping
  • Chromosomes, Human, Pair 1 / ultrastructure*
  • DNA / analysis
  • DNA / genetics
  • Genes / genetics*
  • Humans
  • Hybrid Cells / analysis
  • Hybrid Cells / cytology
  • Hybrid Cells / ultrastructure
  • Molecular Sequence Data
  • Muscle Proteins / genetics*
  • Muscles / analysis*
  • Muscles / physiology
  • Rodentia

Substances

  • Calsequestrin
  • Muscle Proteins
  • DNA