Mast cell sarcoma: clinical management

Immunol Allergy Clin North Am. 2014 May;34(2):423-32. doi: 10.1016/j.iac.2014.01.004. Epub 2014 Mar 13.

Abstract

Mast cell sarcoma is a disorder that results in abnormal mast cells as identified by morphology, special stains, and in some publications, c-kit mutation analysis. It affects animal species such as canines more commonly than humans. In humans it is a very rare condition, with variable clinical presentation. There is no standard therapy for the disorder. It can affect any age group. It is occasionally associated with systemic mastocytosis and/or urticaria pigmentosa. The prognosis of mast cell sarcoma in published literature is very poor in humans.

Keywords: Clinical presentation of mast cell sarcoma; Mast cell sarcoma; Mastocytosis; Prognosis of mast cell sarcoma; Treatment of mast cell sarcoma.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Aged
  • Animals
  • Bone and Bones / drug effects
  • Bone and Bones / metabolism
  • Bone and Bones / pathology
  • Bone and Bones / surgery
  • Child
  • Colon / drug effects
  • Colon / metabolism
  • Colon / pathology
  • Colon / surgery
  • Disease Progression
  • Dogs
  • Female
  • Humans
  • Larynx / drug effects
  • Larynx / metabolism
  • Larynx / pathology
  • Larynx / surgery
  • Male
  • Mast Cells / drug effects
  • Mast Cells / metabolism
  • Mast Cells / pathology
  • Mast-Cell Sarcoma / drug therapy*
  • Mast-Cell Sarcoma / metabolism
  • Mast-Cell Sarcoma / pathology
  • Mast-Cell Sarcoma / surgery*
  • Prognosis
  • Protein Kinase Inhibitors / therapeutic use

Substances

  • Protein Kinase Inhibitors