Several studies have investigated whether MTHFR rs1801133 polymorphism contributes to risk of colorectal cancer (CRC), however the results are inconclusive.
Aim: The purpose of this study was to investigate this hypothesis in a case-control study and meta-analysis in Iranian population.
Materials & methods: This polymorphism was genotyped in the 2421 subjects (46% CRC patients) from Tehran. Meta-analysis was performed for determining the risk effect size of this polymorphism on CRC.
Results: Both case-control study and meta-analysis showed no association between rs1801133 and CRC risk or its features.
Conclusion: This study failed to identify an association between the rs1801133 and susceptibility to CRC in Iranian population.
Keywords: MTHFR; colorectal cancer; meta-analysis; polymorphism; susceptibility.