Phaeochromocytoma and Paraganglioma

Adv Exp Med Biol. 2017:956:239-259. doi: 10.1007/5584_2016_76.

Abstract

Phaeochromocytomas and paragangliomas are relatively uncommon tumours which may be manifest in many ways, specifically as sustained or paroxysmal hypertension, episodes of palpitations, sweating, headache and anxiety, or increasingly as an incidental finding. Recent studies have shown that an increasing number are due to germline mutations. This review concentrates on the diagnosis, biochemistry and treatment of these fascinating tumours.

Keywords: Diagnosis; Malignant; Paragangliomas; Phaeochromocytomas; Review; Treatment.

Publication types

  • Review

MeSH terms

  • Adrenal Gland Neoplasms* / diagnosis
  • Adrenal Gland Neoplasms* / genetics
  • Adrenal Gland Neoplasms* / physiopathology
  • Adrenal Gland Neoplasms* / therapy
  • Blood Pressure
  • Catecholamines / metabolism
  • Genetic Predisposition to Disease
  • Humans
  • Hypertension / etiology
  • Hypertension / physiopathology
  • Paraganglioma* / diagnosis
  • Paraganglioma* / genetics
  • Paraganglioma* / physiopathology
  • Paraganglioma* / therapy
  • Phenotype
  • Pheochromocytoma* / diagnosis
  • Pheochromocytoma* / genetics
  • Pheochromocytoma* / physiopathology
  • Pheochromocytoma* / therapy
  • Predictive Value of Tests
  • Risk Factors
  • Treatment Outcome

Substances

  • Catecholamines