Tongue-lip adhesion and tongue repositioning for obstructive sleep apnoea in Pierre Robin sequence: A systematic review and meta-analysis

J Laryngol Otol. 2017 May;131(5):378-383. doi: 10.1017/S0022215117000056. Epub 2017 Feb 14.

Abstract

Objective: To search for studies on tongue-lip adhesion and tongue repositioning used as isolated treatments for obstructive sleep apnoea in children with Pierre Robin sequence.

Methods: A systematic literature search of PubMed/Medline and three additional databases, from inception through to 8 July 2016, was performed by two authors.

Results: Seven studies with 90 patients (59 tongue-lip adhesion and 31 tongue repositioning patients) met the inclusion criteria. Tongue-lip adhesion reduced the mean (± standard deviation) apnoea/hypopnoea index from 30.8 ± 22.3 to 15.4 ± 18.9 events per hour (50 per cent reduction). The apnoea/hypopnoea index mean difference for tongue-lip adhesion was -15.28 events per hour (95 per cent confidence interval = -30.70 to 0.15; p = 0.05). Tongue-lip adhesion improved the lowest oxygen saturation from 75.8 ± 6.8 to 84.4 ± 7.3 per cent. Tongue repositioning reduced the apnoea/hypopnoea index from 46.5 to 17.4 events per hour (62.6 per cent reduction). Tongue repositioning improved the mean oxygen saturation from 90.8 ± 1.2 to 95.0 ± 0.5 per cent.

Conclusion: Tongue-lip adhesion and tongue repositioning can improve apnoea/hypopnoea index and oxygenation parameters in children with Pierre Robin sequence and obstructive sleep apnoea.

Keywords: Obstructive; Operative; Pierre Robin Syndrome; Sleep Apnea; Surgical Procedures; Tongue.

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Child
  • Humans
  • Lip / surgery*
  • Oxygen Consumption
  • Pierre Robin Syndrome / complications*
  • Severity of Illness Index
  • Sleep Apnea, Obstructive / congenital
  • Sleep Apnea, Obstructive / physiopathology
  • Sleep Apnea, Obstructive / surgery*
  • Tissue Adhesions
  • Tongue / surgery*
  • Treatment Outcome