Flow Cytometry of T cells and T-cell Neoplasms

Jeffrey W Craig; David M Dorfman

doi:10.1016/j.cll.2017.07.002

Flow Cytometry of T cells and T-cell Neoplasms

Clin Lab Med. 2017 Dec;37(4):725-751. doi: 10.1016/j.cll.2017.07.002. Epub 2017 Oct 3.

Authors

Jeffrey W Craig¹, David M Dorfman²

Affiliations

¹ Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
² Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. Electronic address: ddorfman@bwh.harvard.edu.

PMID: 29128066
DOI: 10.1016/j.cll.2017.07.002

Abstract

Flow cytometry is ideally suited for the immunophenotypic analysis of T-cell neoplasia. This article covers the spectrum of flow cytometric findings associated with frequently encountered benign and neoplastic T-cell populations and details the most common immunophenotypic features associated with specific neoplasms of both immature and mature T cells.

Keywords: Flow cytometry; Immunophenotypic analysis; Pan T-cell antigens; T-cell neoplasia.

Publication types

Review

MeSH terms

Flow Cytometry*
Humans
Immunophenotyping
Leukemia, T-Cell* / classification
Leukemia, T-Cell* / diagnosis
Lymphoma, T-Cell* / classification
Lymphoma, T-Cell* / diagnosis
T-Lymphocytes / cytology*