Purpose: To describe a rare case of conjunctival colloid milium.
Methods: Case report.
Results: We report a 45-year-old woman with a history of a slow-growing, painless mass extending from the medial canthal region to the inferior fornix and the inferior bulbar conjunctiva associated with redness. The patient underwent excisional biopsy of the lesion with amniotic membrane transplantation for the resulting conjunctival defect. Biopsy showed homogenous amorphous eosinophilic material with gaps. The stroma did not show any evidence of solar damage, and no refractive material was seen under the polarizer. Congo red stain for amyloid was negative. Based on histopathological findings, a diagnosis of nodular colloid milium was made.
Conclusions: Adult periocular colloid milium is an unusual presentation of a rare cutaneous deposition disease. The occurrence of conjunctival colloid milium is rare, and we report this case to increase knowledge and management regarding this rare disease and to differentiate it from other diseases such as amyloidosis, lipoid proteinosis, plasmacytoma, and conjunctival lymphoma, which carry a graver prognosis, and have a similar clinical appearance and can be distinguished only on the basis of histopathological characteristics.