Abstract
The significance of quantitative changes of ALDH1A1 and RDH10 gene expression in 22 non-treated multiple myeloma patients were studied. We found a direct correlation between the expression of ALDH1A1 and RDH10 genes. We showed that ALDHA1 and RDH10 expression were inversely related with expression of a key gene for all-trans-retinoic acid catabolism, CYP26A1, and correlated with expression of RARα and PPARβ/ genes. In addition for the first time it was re- vealed that increased expression of ALDH1A1-RDH10-RARα- PPARβ/δ pattern could be considered as adverse prognostic factor associated with a higher concentration of paraprotein and worst overall survival of patients with newly diagnosed multiple myeloma.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Alcohol Oxidoreductases / biosynthesis*
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Alcohol Oxidoreductases / genetics
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Aldehyde Dehydrogenase / biosynthesis*
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Aldehyde Dehydrogenase / genetics
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Aldehyde Dehydrogenase 1 Family
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Female
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Gene Expression Regulation, Neoplastic*
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Humans
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Male
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Middle Aged
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Multiple Myeloma* / genetics
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Multiple Myeloma* / metabolism
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Multiple Myeloma* / mortality
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Multiple Myeloma* / pathology
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Neoplasm Proteins / biosynthesis*
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Neoplasm Proteins / genetics
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PPAR delta / biosynthesis*
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PPAR delta / genetics
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PPAR-beta / biosynthesis*
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PPAR-beta / genetics
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Retinal Dehydrogenase
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Retinoic Acid Receptor alpha / biosynthesis*
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Retinoic Acid Receptor alpha / genetics
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Tretinoin / metabolism*
Substances
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Neoplasm Proteins
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PPAR delta
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PPAR-beta
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Retinoic Acid Receptor alpha
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Tretinoin
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Alcohol Oxidoreductases
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trans-retinol dehydrogenase
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Aldehyde Dehydrogenase 1 Family
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Aldehyde Dehydrogenase
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ALDH1A1 protein, human
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Retinal Dehydrogenase