The aim of this study was to investigate the clinical diagnostic value of combined detection of serum C-reactive protein (CRP) and procalcitonin (PCT) for bacterial infectious diseases in children. It was a case control study carried out from October 2016 to March 2018. A total of 150 children with bacterial infectious disease were assigned to the observation group, and 150 healthy children without infectious diseases were assigned to the control group. The research showed that CRP and PCT levels, positive rates of CRP and PCT detection in observation group were higher than those in control group (p<0.001); sensitivity and diagnostic coincidence rate, detection specificity of CRP combined with PCT were higher than those in single PCT or CRP (p<0.001, <0.001 and 0.013, respectively). CRP combined with PCT detection enjoys good clinical application value in diagnosis of bacterial infectious diseases in children.