Abstract
Introduction: The classification of lymphomas is based on the postulated normal counterparts of lymphoid neoplasms and currently constitutes over 100 definite or provisional entities. As this number of entities implies, lymphomas show marked pathological, genetic, and clinical heterogeneity. Recent molecular findings have significantly advanced our understanding of lymphomas. Areas covered: The World Health Organization (WHO) classification of lymphoid neoplasms was updated in 2017. The present review summarizes the new findings that have been gained in the areas of mature T-cell neoplasms, Hodgkin lymphomas, and histiocytic/dendritic cell neoplasms since the publication of the 2017 WHO classification. Expert opinion: Although formal revisions to the WHO classification are published only periodically, our understanding of the pathologic, genetic, and clinical features of lymphoid neoplasms is constantly evolving, particularly in the age of -omics technologies and targeted therapeutics. Even in the relatively short time since the publication of the 2017 WHO classification, many significant findings have been identified in the entities covered in this review.
Keywords:
Adult T-cell leukemia/lymphoma; EBV-associated T-/NK-cell neoplasms; Hodgkin lymphoma; WHO classification; genetic abnormalities; histiocytic/dendritic cell tumors; mature T-cell neoplasms.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Biomarkers, Tumor / genetics
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Biomarkers, Tumor / immunology
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Burkitt Lymphoma / classification*
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Burkitt Lymphoma / diagnosis
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Burkitt Lymphoma / genetics
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Burkitt Lymphoma / immunology
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Dendritic Cells / immunology
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Dendritic Cells / pathology
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Epstein-Barr Virus Infections / classification*
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Epstein-Barr Virus Infections / diagnosis
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Epstein-Barr Virus Infections / genetics
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Epstein-Barr Virus Infections / immunology
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Hematologic Neoplasms / classification*
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Hematologic Neoplasms / diagnosis
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Hematologic Neoplasms / genetics
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Hematologic Neoplasms / immunology
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Histiocytic Disorders, Malignant / classification*
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Histiocytic Disorders, Malignant / diagnosis
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Histiocytic Disorders, Malignant / genetics
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Histiocytic Disorders, Malignant / immunology
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Hodgkin Disease / classification*
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Hodgkin Disease / diagnosis
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Hodgkin Disease / genetics
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Hodgkin Disease / immunology
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Humans
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Killer Cells, Natural / immunology
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Killer Cells, Natural / pathology
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Lymphoma, T-Cell / classification*
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Lymphoma, T-Cell / diagnosis
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Lymphoma, T-Cell / genetics
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Lymphoma, T-Cell / immunology
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Macrophages / immunology
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Macrophages / pathology
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Neoplasm Proteins / genetics
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Neoplasm Proteins / immunology
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T-Lymphocytes / immunology
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T-Lymphocytes / pathology
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Terminology as Topic
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World Health Organization
Substances
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Biomarkers, Tumor
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Neoplasm Proteins