A meta-analysis on associations of FTO, MTHFR and TCF7L2 polymorphisms with polycystic ovary syndrome

Genomics. 2020 Mar;112(2):1516-1521. doi: 10.1016/j.ygeno.2019.08.023. Epub 2019 Aug 27.

Abstract

Background: We aimed to better clarify the relationship between FTO/MTHFR/TCF7L2 polymorphisms and PCOS in a larger combined population by performing a meta-analysis.

Methods: Eligible articles were retrieved from Pubmed, Embase, Web of Science and CNKI. Review Manager Version was used to perform statistical analyses.

Results: Forty-six studies were included for this meta-analysis. FTO rs9939609 polymorphism was found to be significantly associated with PCOS under dominant, recessive, over-dominant and allele comparisons, MTHFR rs1801131 polymorphism was found to be significantly associated with PCOS under recessive and allele comparisons, and MTHFR rs1801133 polymorphism was also found to be significantly associated with PCOS under dominant, recessive and allele comparisons in general population. In subgroup analyses, we found that positive results were mainly driven by the Asians.

Conclusions: Collectively, this meta-analysis proved that FTO rs9939609, MTHFR rs1801131 and MTHFR rs1801133 polymorphisms may serve as predisposing factors of PCOS, especially for Asians.

Keywords: Fat mass and obesity associated protein (FTO); Meta-analysis; Methylenetetrahydrofolate reductase (MTHFR); Polycystic ovary syndrome (PCOS); Transcription factor 7 like 2 (TCF7L2).

Publication types

  • Meta-Analysis

MeSH terms

  • Alpha-Ketoglutarate-Dependent Dioxygenase FTO / genetics*
  • Female
  • Humans
  • Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
  • Polycystic Ovary Syndrome / genetics*
  • Polymorphism, Single Nucleotide*
  • Transcription Factor 7-Like 2 Protein / genetics*

Substances

  • TCF7L2 protein, human
  • Transcription Factor 7-Like 2 Protein
  • Alpha-Ketoglutarate-Dependent Dioxygenase FTO
  • FTO protein, human
  • MTHFR protein, human
  • Methylenetetrahydrofolate Reductase (NADPH2)