Developmental processes are cascades of biological changes linked with information transfer, growth, and differentiation during the life cycle of an organism. Lipid metabolism plays a vital role in the life cycle of organisms. Drosophila models grant numerous advantages in investigating the underlying mechanisms of each process as well as their connections. In each section of this review, we will discuss multiple studies revealing the function of lipid-related genes in different stages of early development: spermatogenesis, oogenesis, embryogenesis along with late development in life cycle of Drosophila.