Type 1 diabetes and MIG

In Type 1 Diabetes (T1D), the monokine induced by interferon (IFN)-γ (MIG)/(C-X-C motif) receptor (CXCR)3 axis has a crucial role in β-cell destruction and in the autoimmune process of the disease, like many papers have reported. In fact, in T1D subjects the serum levels of the Type helper 1 chemokine MIG is increased, suggesting that this chemokine could be a predictive marker of T1D. Moreover, the pathophysiology of the disease course could be assessed by measuring MIG serum levels. A potential approach for T1D therapy could be the block of MIG expression at the beginning of the disease. Anyway, the chemokines-cytokines interactions in the T1D pathogenesis need to be further investigated.